The ability of cells to deal with different types of stressful situations in a precise and
coordinated manner is key for survival and involves various signalling networks. Over the …

A variety of nuclear magnetic resonance (NMR) applications have been developed for
structure-based drug discovery (SBDD). NMR provides many advantages over other …

INTRODUCTION Protein kinases mediate many cell signaling processes. Central to their
physiological function is the regulation of their binding and enzymatic activities, which is …

Many kinases use reversible docking interactions to augment the specificity of their catalytic
domains. Such docking interactions are often structurally independent of the catalytic …

The last five years have witnessed major developments in the understanding of the allosteric
phenomenon, broadly defined as coupling between remote molecular sites. Such advances …

Despite the efforts of pharmaceutical companies to develop specific kinase modulators, few
drugs targeting kinases have been completely successful in the clinic. This is primarily due …

Mitogen-activated protein kinases, which include p38, are essential for cell differentiation
and autophagy. The current model for p38 activation involves activation-loop …

p38α is a Ser/Thr protein kinase involved in a variety of cellular processes and pathological
conditions, which makes it a promising pharmacological target. Although the activity of the …

Triple‐negative breast cancer (TNBC) is a highly lethal malignancy with limited therapy
options. TWIST1, a key transcriptional factor of epithelial‐mesenchymal transition (EMT) …

Group 3 innate lymphoid cells (ILC3s) are important for maintaining gut homeostasis. Upon
stimulation, ILC3s can rapidly produce cytokines to protect against infections and colitis …