Structural basis of dual activation of cell division by the actinobacterial transcription factors WhiA and WhiB

M Lilic, NA Holmes, MJ Bush, AK Marti… - Proceedings of the …, 2023 - National Acad Sciences
Studies of transcriptional initiation in different bacterial clades reveal diverse molecular
mechanisms regulating this first step in gene expression. The WhiA and WhiB factors are …

Cytoplasmic contractile injection systems mediate cell death in Streptomyces

B Casu, JW Sallmen, S Schlimpert, M Pilhofer - Nature Microbiology, 2023 - nature.com
Contractile injection systems (CIS) are bacteriophage tail-like structures that mediate
bacterial cell–cell interactions. While CIS are highly abundant across diverse bacterial …

The Best of Both Worlds—Streptomyces coelicolor and Streptomyces venezuelae as Model Species for Studying Antibiotic Production and Bacterial Multicellular …

S Schlimpert, MA Elliot - Journal of Bacteriology, 2023 - Am Soc Microbiol
Streptomyces bacteria have been studied for more than 80 years thanks to their ability to
produce an incredible array of antibiotics and other specialized metabolites and their …

Establishment of an Efficient Expression and Regulation System in Streptomyces for Economical and High-Level Production of the Natural Blue Pigment Indigoidine

M Zhao, XS Zhang, LB Xiong, K Liu, XF Li… - Journal of Agricultural …, 2023 - ACS Publications
Indigoidine, as a kind of natural blue pigment, is widely used in textiles, food, and
pharmaceuticals and is mainly synthesized from l-glutamine via a condensation reaction by …

Discovery of the Pendulisporaceae: An extremotolerant myxobacterial family with distinct sporulation behavior and prolific specialized metabolism

R Garcia, A Popoff, CD Bader, J Löhr, S Walesch… - Chem, 2024 - cell.com
Myxococcota represents a small bacterial phylum comprising seven families, which have
been shown to be exceptionally rich producers of pharmaceutically interesting natural …

[HTML][HTML] The SepF-like proteins SflA and SflB prevent ectopic localization of FtsZ and DivIVA during sporulation of Streptomyces coelicolor

L Zhang, J Willemse, P Yagüe, E de Waal… - Biochemical and …, 2023 - Elsevier
Bacterial cytokinesis starts with the polymerization of the tubulin-like FtsZ, which forms the
cell division scaffold. SepF aligns FtsZ polymers and also acts as a membrane anchor for the …

FtsZ phosphorylation pleiotropically affects Z-ladder formation, antibiotic production, and morphogenesis in Streptomyces coelicolor

P Yagüe, J Willemse, X Xiao, L Zhang… - Antonie van …, 2023 - Springer
Abstract The GTPase FtsZ forms the cell division scaffold in bacteria, which mediates the
recruitment of the other components of the divisome. Streptomycetes undergo two different …

A dispensable SepIVA orthologue in Streptomyces venezuelae is associated with polar growth and not cell division

BC Sen, PS Mavi, O Irazoki, S Datta, S Kaiser, F Cava… - BMC microbiology, 2024 - Springer
Background SepIVA has been reported to be an essential septation factor in
Mycolicibacterium smegmatis and Mycobacterium tuberculosis. It is a coiled-coil protein with …

DNA damage-induced block of sporulation in Streptomyces venezuelae involves downregulation of ssgB

JVT Falguera, KJ Stratton, MJ Bush, C Jani… - …, 2022 - microbiologyresearch.org
DNA damage often causes an arrest of the cell cycle that provides time for genome integrity
to be restored. In bacteria, the classical SOS DNA damage response leads to an inhibition of …

Cytoplasmic contractile injection systems mediate cell death in Streptomyces

B Casu, JW Sallmen, S Schlimpert, M Pilhofer - bioRxiv, 2022 - biorxiv.org
Contractile injection systems (CISs) are bacteriophage tail-like structures that mediate
bacterial cell-cell interactions. While CISs are highly abundant across diverse bacterial …