Two-photon imaging for non-invasive corneal examination

A Batista, P Guimarães, JP Domingues, MJ Quadrado… - Sensors, 2022 - mdpi.com
Two-photon imaging (TPI) microscopy, namely, two-photon excited fluorescence (TPEF),
fluorescence lifetime imaging (FLIM), and second-harmonic generation (SHG) modalities …

Skin cancer detection with a compact multimodal fiber laser multiphoton FLIM tomograph

K König, D Pankin, A Paudel, H Hänßle… - … Microscopy in the …, 2021 - spiedigitallibrary.org
A clinical multicenter study has been performed on patients with suspicious, potentially
malignant, pigmented skin lesions to evaluate the femtosecond fiber laser based compact …

Clinical multimodal multiphoton tomography of pigmented skin lesions with an ultracompact femtosecond fiber laser

K König, A Batista, M Zieger, M Kaatz… - … in Dermatology and …, 2020 - spiedigitallibrary.org
Multiphoton tomography (MPT) has become a high-resolution label-free clinical imaging tool
to obtain optical skin biopsies for rapid in vivo histology. Here, we report on the novel …

Reflectance confocal microscopy of human skin using near infrared femtosecond laser pulses

A König, K König - Multiphoton Microscopy in the Biomedical …, 2022 - spiedigitallibrary.org
The optical properties of the skin including reflectance are affected by aging, dehydration,
and diseases and, therefore, can be used for non-invasive diagnosis. Multiphoton …

In vivo two-photon imaging of topically applied care cosmetics and pharmaceuticals in human skin

A König, K König - Multiphoton Microscopy in the Biomedical …, 2023 - spiedigitallibrary.org
We applied femtosecond laser multiphoton tomographs, including the novel system
MPTcompact with its chiller-free fiber laser positioned inside the measurement head, for …

Assessment of Extramammary Paget Disease by Two-Photon Microscopy

R Hristu, LG Eftimie, SG Stanciu, RR Glogojeanu… - Frontiers in …, 2022 - frontiersin.org
Two-photon microscopy techniques are non-linear optical imaging methods which are
gaining momentum in the investigation of fixed tissue sections, fresh tissue or even for in …

history of multiphoton tomography

K König - Multiphoton Microscopy in the Biomedical Sciences …, 2023 - spiedigitallibrary.org
Two decades ago, the very first prototype of a multiphoton tomograph was built and
delivered as a high-resolution skin imaging device to the cosmetic company Beiersdorf AG …