Artemisinin-based combination therapies (ACTs) have substantially reduced worldwide
malaria burden and deaths. But malaria parasites have become resistant to artemisinins …

Malaria is one of the three most deadly infectious diseases in the world and seriously
endangers human health and life. To reduce the public health burden of this disease …

Background DSM265 is a novel antimalarial that inhibits plasmodial dihydroorotate
dehydrogenase, an enzyme essential for pyrimidine biosynthesis. We investigated the …

Here, we report the application of a portable sequencer, MinION, for genotyping the malaria
parasite Plasmodium falciparum. In the present study, an amplicon mixture of nine …

Abstract Background In 2005, the Democratic Republic of the Congo (DRC) switched to
artesunate/amodiaquine as the first-line antimalarial in response to increasing sulfadoxine …

Microscopic detection and morphological identification of parasites from clinical specimens
are the gold standards for the laboratory diagnosis of parasitic infections. The limitations of …

Resistance has developed in Plasmodium malaria parasites to every antimalarial drug in
clinical use, prompting the need to characterize the pathways mediating resistance. Here …

Background India is on track to eliminate malaria by 2030 but emerging resistance to first-
line antimalarials is a recognised threat. Two instances of rapid development, spread, and …

Abstract The Malaria Box, assembled by the Medicines for Malaria Venture, is a set of 400
structurally diverse, commercially available compounds with demonstrated activity against …

Abstract Objective: Drug resistance against Plasmodium falciparum has been recognized as
the crucial obstacle to curbing mortality and morbidity from malaria. To investigate the …