This paper discusses the current evidence from animal and human studies for a central role
of inflammation in schizophrenia. In animal models, pre-or perinatal elicitation of the immune …

Complex interactions between the immune system and the brain might have important
aetiological and therapeutic implications for neuropsychiatric brain disorders. A possible …

Schizophrenia is a psychiatric disorder which has a lifetime prevalence of~ 1%. Multiple
candidate mechanisms have been proposed in the pathogenesis of schizophrenia. One …

Over the past decade, our understanding of the role of stress in serious mental illness has
become more sophisticated. In this paper, we revisit the neural diathesis-stress model of …

BACKGROUND: Schizophrenia is associated with immune system dysfunction, including
aberrant cytokine levels. We performed a meta-analysis of these associations, considering …

BackgroundAccumulating evidence shows that a propensity towards a pro-inflammatory
status in the brain plays an important role in schizophrenia. Anti-inflammatory drugs might …

Upregulation of the immune response may be involved in the pathogenesis of schizophrenia
with changes occurring in both peripheral blood and brain tissue. To date, microarray …

Since the introduction of chlorpromazine and throughout the development of the new-
generation antipsychotic drugs (APDs) beginning with clozapine, the D 2 receptor has been …

Infections and inflammatory processes have been associated with the development of
schizophrenia and affective disorders; however, no study has yet systematically reviewed all …

Schizophrenia is a serious mental illness with chronic symptoms and significant impairment
in psychosocial functioning. Although novel antipsychotics have been developed, the …