The role of extracelluar matrix in osteosarcoma progression and metastasis

J Cui, D Dean, FJ Hornicek, Z Chen, Z Duan - Journal of Experimental & …, 2020 - Springer
Osteosarcoma (OS) is the most common primary bone malignancy and responsible for
considerable morbidity and mortality due to its high rates of pulmonary metastasis. Although …

The role of gut microbiota in intestinal disease: From an oxidative stress perspective

Y Sun, X Wang, L Li, C Zhong, Y Zhang… - Frontiers in …, 2024 - frontiersin.org
Recent studies have indicated that gut microbiota-mediated oxidative stress is significantly
associated with intestinal diseases such as colorectal cancer, ulcerative colitis, and Crohn's …

Establishment of a large-scale patient-derived high-risk colorectal adenoma organoid biobank for high-throughput and high-content drug screening

Z Luo, B Wang, F Luo, Y Guo, N Jiang, J Wei, X Wang… - BMC medicine, 2023 - Springer
Background Colorectal adenoma (CA), especially high-risk CA (HRCA), is a precancerous
lesion with high prevalence and recurrence rate and accounts for about 90% incidence of …

Patterns of somatic variants in colorectal adenoma and carcinoma tissue and matched plasma samples from the hungarian oncogenome program

A Kalmár, O Galamb, G Szabó, O Pipek… - Cancers, 2023 - mdpi.com
Simple Summary Colorectal cancer is a highly lethal cancer type with a high incidence and
mortality rate in Hungary. To explore the genetic background behind this epidemiological …

New transcriptomic biomarkers of 5-fluorouracil resistance

JT Fekete, B Győrffy - International Journal of Molecular Sciences, 2023 - mdpi.com
The overall response rate to fluoropyrimidine monotherapy in colorectal cancer (CRC) is
limited. Transcriptomic datasets of CRC patients treated with 5-fluorouracil (5FU) could …

Genomic, microbial and immunological microenvironment of colorectal polyps

BCY Tse, Z Welham, AF Engel, MP Molloy - Cancers, 2021 - mdpi.com
Simple Summary Colorectal cancers (CRC) initiate from small cell clusters known as polyps.
Colonoscopic surveillance and removal of polyps is an important strategy to prevent CRC …

Exploration of the Key Proteins in the Normal‐Adenoma‐Carcinoma Sequence of Colorectal Cancer Evolution Using In‐Depth Quantitative Proteomics

Y Zhang, CY Li, W Ge, Y Xiao - Journal of Oncology, 2021 - Wiley Online Library
Purpose. In most cases, the carcinogenesis of colorectal cancer (CRC) follows the normal‐
adenoma‐carcinoma (N‐A‐C) sequence. In this study, we aimed to identify the key proteins …

[Retracted] Identification of Key MicroRNAs and Genes between Colorectal Adenoma and Colorectal Cancer via Deep Learning on GEO Databases and …

X Zhang, M Jin, F Liu, H Qu… - Contrast Media & …, 2023 - Wiley Online Library
Background. Deep learning techniques are gaining momentum in medical research.
Colorectal adenoma (CRA) is a precancerous lesion that may develop into colorectal cancer …

Discovering Innate Driver Variants for Risk Assessment of Early Colorectal Cancer Metastasis

RF Ding, Y Zhang, LY Wu, P You, ZX Fang, ZY Li… - Frontiers in …, 2022 - frontiersin.org
Metastasis is the main fatal cause of colorectal cancer (CRC). Although enormous efforts
have been made to date to identify biomarkers associated with metastasis, there is still a …

The gut microbiome in colorectal adenomas

ZM Welham - 2024 - ses.library.usyd.edu.au
How the gut microbiome is altered in patients with bowel polyps and contributes to polyp
progression is poorly understood. This thesis investigated the microbiome in early bowel …