How to make a midbrain dopaminergic neuron
Midbrain dopaminergic (mDA) neuron development has been an intense area of research
during recent years. This is due in part to a growing interest in regenerative medicine and …
during recent years. This is due in part to a growing interest in regenerative medicine and …
Neurotrophic factors: an overview
SD Skaper - Neurotrophic Factors: Methods and Protocols, 2018 - Springer
The neurotrophins are a family of closely related proteins that were first identified as survival
factors for sympathetic and sensory neurons and have since been shown to control a …
factors for sympathetic and sensory neurons and have since been shown to control a …
The neurotrophin family of neurotrophic factors: an overview
SD Skaper - Neurotrophic factors: Methods and protocols, 2012 - Springer
The neurotrophins are a family of closely related proteins that were first identified as survival
factors for sympathetic and sensory neurons and have since been shown to control a …
factors for sympathetic and sensory neurons and have since been shown to control a …
Event‐related beta desynchronization in human subthalamic nucleus correlates with motor performance
Although the basal ganglia play an important role in self‐generated movement, their
involvement in externally paced voluntary movement is less clear. We recorded local field …
involvement in externally paced voluntary movement is less clear. We recorded local field …
Randomized controlled trial of intraputamenal glial cell line–derived neurotrophic factor infusion in Parkinson disease
Objective Glial cell line–derived neurotrophic factor (GDNF) exerts potent trophic influence
on midbrain dopaminergic neurons. This randomized controlled clinical trial was designed …
on midbrain dopaminergic neurons. This randomized controlled clinical trial was designed …
Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
Lentiviral delivery of glial cell line–derived neurotrophic factor (lenti-GDNF) was tested for its
trophic effects upon degenerating nigrostriatal neurons in nonhuman primate models of …
trophic effects upon degenerating nigrostriatal neurons in nonhuman primate models of …
Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons
O Saucedo-Cardenas… - Proceedings of the …, 1998 - National Acad Sciences
Nurr1 is a member of the nuclear receptor superfamily of transcription factors that is
expressed predominantly in the central nervous system, including developing and mature …
expressed predominantly in the central nervous system, including developing and mature …
The role of neuronal growth factors in neurodegenerative disorders of the human brain
B Connor, M Dragunow - Brain Research Reviews, 1998 - Elsevier
Recent evidence suggests that neurotrophic factors that promote the survival or
differentiation of developing neurons may also protect mature neurons from neuronal …
differentiation of developing neurons may also protect mature neurons from neuronal …
NURR1 in Parkinson disease—from pathogenesis to therapeutic potential
M Decressac, N Volakakis, A Björklund… - Nature Reviews …, 2013 - nature.com
In Parkinson disease (PD), affected midbrain dopamine (DA) neurons lose specific
dopaminergic properties before the neurons die. How the phenotype of DA neurons is …
dopaminergic properties before the neurons die. How the phenotype of DA neurons is …
Prospects for new restorative and neuroprotective treatments in Parkinson's disease
SB Dunnett, A Björklund - Nature, 1999 - nature.com
The degeneration of forebrain dopamine systems in Parkinson's disease has been an
effective target for pharmaceutical research over the past four decades. However, although …
effective target for pharmaceutical research over the past four decades. However, although …