The neurotrophins are a family of closely related proteins that were first identified as survival factors for sympathetic and sensory neurons and have since been shown to control a …
The neurotrophins are a family of closely related proteins that were first identified as survival factors for sympathetic and sensory neurons and have since been shown to control a …
Although the basal ganglia play an important role in self‐generated movement, their involvement in externally paced voluntary movement is less clear. We recorded local field …
Lentiviral delivery of glial cell line–derived neurotrophic factor (lenti-GDNF) was tested for its trophic effects upon degenerating nigrostriatal neurons in nonhuman primate models of …
O Saucedo-Cardenas… - Proceedings of the …, 1998 - National Acad Sciences
Nurr1 is a member of the nuclear receptor superfamily of transcription factors that is expressed predominantly in the central nervous system, including developing and mature …
Recent evidence suggests that neurotrophic factors that promote the survival or differentiation of developing neurons may also protect mature neurons from neuronal …
M Decressac, N Volakakis, A Björklund… - Nature Reviews …, 2013 - nature.com
In Parkinson disease (PD), affected midbrain dopamine (DA) neurons lose specific dopaminergic properties before the neurons die. How the phenotype of DA neurons is …
SB Dunnett, A Björklund - Nature, 1999 - nature.com
The degeneration of forebrain dopamine systems in Parkinson's disease has been an effective target for pharmaceutical research over the past four decades. However, although …