Acidic extracellular pH is a major feature of tumor tissue, extracellular acidification being
primarily considered to be due to lactate secretion from anaerobic glycolysis …

This work presents a review of pH measurement methods and applications in cancers.
Magnetic resonance spectroscopic imaging and magnetic resonance imaging …

Pathologists have recognized arterial calcification for over a century. Recent years have
witnessed a strong resurgence of interest in atherosclerotic plaque calcification because it …

Animal models are fundamental to advance our knowledge of the underlying
pathophysiology of bone loss and to study pharmaceutical countermeasures against it. The …

Abstract Vacuolar-type ATPase (V-ATPase), initially identified in yeast and plant vacuoles,
pumps protons into the lumen of organelles coupled with ATP hydrolysis. The mammalian …

Background Feature selection is a critical step for translating advances afforded by systems-
scale molecular profiling into actionable clinical insights. While data-driven methods are …

Carbonic anhydrases (CAs) catalyze a reaction fundamental for life: the bidirectional
conversion of carbon dioxide (CO2) and water (H2O) into bicarbonate (HCO3−) and protons …

Cigarette smoking (CS) leads to significant bone loss, which is recognized as an
independent risk factor for osteoporosis. The number of smokers is continuously increasing …

Osteoclasts resorb bone by attaching to the surface and then secreting protons into an
extracellular compartment formed between osteoclast and bone surface. This secretion is …

The success of scaffold‐based bone regeneration approaches strongly depends on the
performance of the biomaterial utilized. Within the efforts of regenerative medicine towards a …