Heterochromatin is a key characteristic of eukaryotic genomes. Since its cytological
description nearly 100 years ago, our understanding of heterochromatin features and …

Recent experimental observations suggest a strong coupling between the 3D nuclear
chromosome organization and epigenomics. However, the mechanistic and functional …

Cells remember their identities, in part, by using epigenetic marks—chemical modifications
placed along the genome. How can mark patterns remain stable over cell generations …

The immune system encodes information about the severity of a pathogenic threat in the
quantity and type of memory cells it forms. This encoding emerges from lymphocyte …

The mechanisms and timescales controlling de novo establishment of chromatin-mediated
transcriptional silencing by Polycomb repressive complex 2 (PRC2) are unclear. Here, we …

Transcriptional silencing through the Polycomb silencing machinery utilizes a" read-write"
mechanism involving histone tail modifications. However, nucleation of silencing and long …

Abstract Polycomb repressive complex 2 (PRC2) mediates epigenetic silencing of target
genes in animals and plants. In Arabidopsis, PRC2 is required for the cold-induced …

Determining whether life can progress arbitrarily slowly may reveal fundamental barriers to
staying out of thermal equilibrium for living systems. By monitoring budding yeast's slowed …

Understanding the mechanistic basis of epigenetic memory has proven to be a difficult task
due to the underlying complexity of the systems involved in its establishment and …

Transcription factors can exert opposite effects depending on the chromosomal context. The
fission yeast transcription factor Atf1 both activates numerous genes in response to stresses …