Kinetic and equilibrium analysis of the myosin ATPase

M Enrique, EM Ostap - Methods in enzymology, 2009 - Elsevier
The myosin superfamily consists of more than 35 classes (each consisting of multiple
isoforms) that have diverse cellular activities. The reaction pathway of the actin‐activated …

Myosin VI: an innovative motor that challenged the swinging lever arm hypothesis

JA Spudich, S Sivaramakrishnan - Nature reviews Molecular cell …, 2010 - nature.com
The swinging crossbridge hypothesis states that energy from ATP hydrolysis is transduced
to mechanical movement of the myosin head while bound to actin. The light chain-binding …

Force and phosphate release from Arp2/3 complex promote dissociation of actin filament branches

NG Pandit, W Cao, J Bibeau… - Proceedings of the …, 2020 - National Acad Sciences
Networks of branched actin filaments formed by Arp2/3 complex generate and experience
mechanical forces during essential cellular functions, including cell motility and endocytosis …

Oxidation of aldehydes into carboxylic acids by a mononuclear manganese (III) iodosylbenzene complex through electrophilic C–H bond activation

D Jeong, H Kim, J Cho - Journal of the American Chemical …, 2023 - ACS Publications
The oxidation of aldehyde is one of the fundamental reactions in the biological system.
Various synthetic procedures and catalysts have been developed to convert aldehydes into …

Cold Denaturation of α‐Synuclein Amyloid Fibrils

T Ikenoue, YH Lee, J Kardos, M Saiki… - Angewandte Chemie …, 2014 - Wiley Online Library
Although amyloid fibrils are associated with numerous pathologies, their conformational
stability remains largely unclear. Herein, we probe the thermal stability of various amyloid …

What limits the velocity of fast-skeletal muscle contraction in mammals?

M Nyitrai, R Rossi, N Adamek, MA Pellegrino… - Journal of molecular …, 2006 - Elsevier
In rat skeletal muscle the unloaded shortening velocity (Vo) is defined by the myosin isoform
expressed in the muscle fibre. In 2001 we suggested that ADP release from actomyosin in …

ATP utilization and RNA conformational rearrangement by DEAD-box proteins

A Henn, MJ Bradley… - Annual review of …, 2012 - annualreviews.org
RNA helicase enzymes catalyze the in vivo folding and conformational re-arrangement of
RNA. DEAD-box proteins (DBPs) make up the largest family of RNA helicases and are found …

[HTML][HTML] Mitochondrial respiration and membrane potential are regulated by the allosteric ATP-inhibition of cytochrome c oxidase

R Ramzan, K Staniek, B Kadenbach, S Vogt - Biochimica et Biophysica …, 2010 - Elsevier
This paper describes the problems of measuring the allosteric ATP-inhibition of cytochrome
c oxidase (CcO) in isolated mitochondria. Only by using the ATP-regenerating system …

The ATPase cycle mechanism of the DEAD-box rRNA helicase, DbpA

A Henn, W Cao, DD Hackney, M Enrique - Journal of molecular biology, 2008 - Elsevier
DEAD-box proteins are ATPase enzymes that destabilize and unwind duplex RNA.
Quantitative knowledge of the ATPase cycle parameters is critical for developing models of …

Direct observation of the myosin-Va power stroke and its reversal

JR Sellers, C Veigel - Nature structural & molecular biology, 2010 - nature.com
Complex forms of cellular motility, including cell division, organelle trafficking or signal
amplification in the auditory system, require strong coordination of the myosin motors …