Role of Hedgehog and Hippo signaling pathways in cancer: a special focus on non-coding RNAs

U Sharma, HS Tuli, V Uttam, R Choudhary… - Pharmacological …, 2022 - Elsevier
Despite advanced clinical and translational oncology research, mortality rates are still
increasing worldwide. Recently, a class of non-coding RNAs (ncRNAs), such as microRNAs …

LncRNA NEAT1 facilitates glioma progression via stabilizing PGK1

J Liang, C Liu, D Xu, K Xie, A Li - Journal of translational medicine, 2022 - Springer
Abstract Background Long noncoding RNA NEAT1 has been implicated in glioma
progression. However, the effect of NEAT1 on glycolysis of glioma cell and the potential …

LncRNAs and related molecular basis in malignant pleural mesothelioma: Challenges and potential

X Xu, H Li, M Xie, Z Zhou, D Wang, W Mao - Critical Reviews in Oncology …, 2023 - Elsevier
Malignant pleural mesothelioma (MPM) is a rare but invasive cancer, which mainly arises
from mesothelial tissues of pleura, peritoneum and pericardium. Despite significant …

LncRNA NEAT1 suppresses cellular senescence in hepatocellular carcinoma via KIF11‐dependent repression of CDKN2A

D Chen, J Wang, Y Li, C Xu… - Clinical and …, 2023 - Wiley Online Library
Background Hepatocellular carcinoma (HCC) is the third leading cause of cancer‐related
deaths worldwide. Therapeutic options for advanced HCC are limited, which is due to a lack …

LncRNA NEAT1 enhances glioma progression via regulating the miR-128-3p/ITGA5 axis

J Chen, H Wang, J Wang, W Niu, C Deng… - Molecular neurobiology, 2021 - Springer
Accumulating evidences indicate that long non-coding RNA nuclear paraspeckle assembly
transcript 1 (NEAT1) promotes the progression of glioma. In this study, we postulated that …

CRISPR-cas9 screening identified lethal genes enriched in Hippo kinase pathway and of predictive significance in primary low-grade glioma

M Mijiti, A Maimaiti, X Chen, M Tuersun, M Dilixiati… - Molecular …, 2023 - Springer
Background Low-grade gliomas (LGG) are a type of brain tumor that can be lethal, and it is
essential to identify genes that are correlated with patient prognosis. In this study, we aimed …

lncRNA Oip5-as1 inhibits excessive mitochondrial fission in myocardial ischemia/reperfusion injury by modulating DRP1 phosphorylation

X Niu, J Zhang, S Hu, W Dang, K Wang… - Cellular & Molecular …, 2024 - Springer
Background Aberrant mitochondrial fission, a critical pathological event underlying
myocardial ischemia/reperfusion (MI/R) injury, has emerged as a potential therapeutic …

Targeting protein kinases in cancer stem cells

CN Chu, TKW Lee - Essays in Biochemistry, 2022 - portlandpress.com
Cancer stem cells (CSCs) are subpopulations of cancer cells within the tumor bulk that have
emerged as an attractive therapeutic target for cancer therapy. Accumulating evidence has …

[HTML][HTML] Interaction of Noncoding RNAs with Hippo Signaling Pathway in Cancer Cells and Cancer Stem Cells

S Abedimanesh, R Safaralizadeh, Z Jahanafrooz… - Non-coding RNA …, 2024 - Elsevier
The Hippo signaling pathway has a regulatory function in the organogenesis process and
cellular homeostasis, switching the cascade reactions of crucial kinases acts to turn off/on …

Long Non-Coding RNAs as Regulators for Targeting Breast Cancer Stem Cells and Tumor Immune Microenvironment: Biological Properties and Therapeutic Potential

F Yang, Y Yang, Y Qiu, L Tang, L Xie, X Guan - Cancers, 2024 - mdpi.com
Simple Summary A number of lncRNAs participate in the stemness-related signaling
pathways. In this article, we provided insights into the emerging data for the interaction …