Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems

TH Baryakova, BH Pogostin, R Langer… - Nature Reviews Drug …, 2023 - nature.com
Poor medication adherence is a pervasive issue with considerable health and
socioeconomic consequences. Although the underlying reasons are generally understood …

Current strategies for improving access and adherence to antiretroviral therapies in resource-limited settings

ML Scanlon, RC Vreeman - HIV/AIDS-Research and Palliative …, 2013 - Taylor & Francis
The rollout of antiretroviral therapy (ART) significantly reduced human immunodeficiency
virus (HIV)-related morbidity and mortality, but good clinical outcomes depend on access …

Preexposure prophylaxis for HIV prevention in a large integrated health care system: adherence, renal safety, and discontinuation

JL Marcus, LB Hurley, CB Hare… - JAIDS Journal of …, 2016 - journals.lww.com
Background: Placebo-controlled and open-label studies have demonstrated the safety and
efficacy of daily oral preexposure prophylaxis (PrEP) in preventing HIV infection, but data …

Adherence to antiretroviral therapy and virologic failure: a meta-analysis

WM Bezabhe, L Chalmers, LR Bereznicki… - Medicine, 2016 - journals.lww.com
Adherence to Antiretroviral Therapy and Virologic Failure: A... : Medicine Adherence to
Antiretroviral Therapy and Virologic Failure: A Meta-Analysis : Medicine Log in or Register …

Guidelines for improving entry into and retention in care and antiretroviral adherence for persons with HIV: evidence-based recommendations from an International …

MA Thompson, MJ Mugavero, KR Amico… - Annals of internal …, 2012 - acpjournals.org
Description: After HIV diagnosis, timely entry into HIV medical care and retention in that care
are essential to the provision of effective antiretroviral therapy (ART). Adherence to ART is …

Antiretroviral therapy adherence, virologic and immunologic outcomes in adolescents compared with adults in southern Africa

JB Nachega, M Hislop, H Nguyen… - JAIDS Journal of …, 2009 - journals.lww.com
Objective: To determine adherence to and effectiveness of antiretroviral therapy (ART) in
adolescents vs. adults in southern Africa. Design: Observational cohort study. Setting: Aid for …

Retention in care: a challenge to survival with HIV infection

TP Giordano, AL Gifford, AC White Jr… - Clinical infectious …, 2007 - academic.oup.com
Background. Patients with human immunodeficiency virus (HIV) infection need lifelong
medical care, but many do not remain in care. The effect of poor retention in care on survival …

Adherence to nonnucleoside reverse transcriptase inhibitor–based HIV therapy and virologic outcomes

JB Nachega, M Hislop, DW Dowdy… - Annals of internal …, 2007 - acpjournals.org
Background: Adherence of 95% or more to unboosted protease regimens is required for
optimal virologic suppression in HIV-1–infected patients. Whether the same is true for …

The combined effect of modern highly active antiretroviral therapy regimens and adherence on mortality over time

VD Lima, R Harrigan, DR Bangsberg… - JAIDS Journal of …, 2009 - journals.lww.com
Objective: To characterize the impact of longitudinal adherence on survival in drug-naive
individuals starting currently recommended highly active antiretroviral therapy (HAART) …

Clinical outcomes and CD4 cell response in children receiving antiretroviral therapy at primary health care facilities in Zambia

C Bolton-Moore, M Mubiana-Mbewe, RA Cantrell… - Jama, 2007 - jamanetwork.com
ContextThe Zambian Ministry of Health provides pediatric antiretroviral therapy (ART) at
primary care clinics in Lusaka, where, despite scale-up of perinatal prevention efforts, many …