Matrix metalloproteinases (MMPs) are proteolytic enzymes belonging to the family of zinc-
dependent endopeptidases that are capable of degrading almost all the proteinaceous …

Dendritic spines are the locus for excitatory synaptic transmission in the brain and thus play
a major role in neuronal plasticity. The ability to alter synaptic connections includes …

Traumatic brain injury (TBI), which leads to disability, dysfunction, and even death, is a
prominent health problem worldwide with no effective treatment. A brain-permeable …

Ischemic brain injury inflicted by stroke and cardiac arrest ranks among the leading causes
of death and long-term disability in the United States. The brain consumes large amounts of …

Background: Chronic neuroinflammation caused by activation of microglia and astrocytes in
the brain contributes to neuronal loss and disease progression in Alzheimer's disease (AD) …

Abstract Coenzyme Q10 (CoQ10) acts by scavenging reactive oxygen species to protect
neuronal cells against oxidative stress in neurodegenerative diseases. The present study …

Fibrosis is an important phenomenon as it can occur early in the pathogenesis of asthma; it
may be associated with disease severity and resistance to therapy. There is a strong …

Background Upregulation of matrix metalloproteinase-9 (MMP-9) has been indicated as one
of the inflammatory biomarkers. In the central nervous system (CNS), the MMP-9 is induced …

Type 2 diabetes mellitus (T2DM) complicated with obstructive sleep apnea (OSA) may
cause neuronal apoptosis and cognitive deficits, but the underlying mechanisms remain …

An elevated level of glucose has been found in the blood of hyperglycemia and diabetes
patients associated with several central nervous system (CNS) complications. These …