Type I interferons (IFNs)(IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties,
including induction by viral infection, activation of shared signaling pathways, and …

Interferons (IFNs) constitute the first line of defense against microbial infections particularly
against viruses. They provide antiviral properties to cells by inducing the expression of …

Type III interferons have been touted as promising therapeutics in outpatients with
coronavirus disease 2019 (COVID-19). We conducted a randomized, single-blind, placebo …

The respiratory tract is constantly exposed to the external environment, and therefore, must
be equipped to respond to and eliminate pathogens. Viral clearance and resolution of …

Interferon-stimulated gene (ISG) products take on a number of diverse roles. Collectively,
they are highly effective at resisting and controlling pathogens. In this review, we begin by …

Interferons (IFNs) are very powerful cytokines, which play a key role in combatting pathogen
infections by controlling inflammation and immune response by directly inducing anti …

When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was
discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs …

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). The ability of our cells to secrete type I …

Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but
whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect …

Type I and III interferons (IFNs) activate similar downstream signaling cascades, but unlike
type I IFNs, type III IFNs (IFNλ) do not elicit strong inflammatory responses in vivo. Here, we …