In contrast to solid cancers, which often require genetic modifications and complex cellular
reprogramming for effective metastatic dissemination, leukaemic cells uniquely possess the …

Autophagy and apoptosis are two important cellular processes with complex and
intersecting protein networks; as such, they have been the subjects of intense investigation …

Cell migration requires sustained forward movement of the plasma membrane at the cell's
front or" leading edge." To date, researchers have uncovered four distinct ways of extending …

Hsp90 is a major molecular chaperone that is expressed abundantly and plays a pivotal role
in assisting correct folding and functionality of its client proteins in cells. The Hsp90 client …

The concept of autophagic cell death was first established based on observations of
increased autophagic markers in dying cells. The major limitation of such a morphology …

The rapid accumulation of knowledge on apoptosis regulation in the 1990s was followed by
the development of several experimental anticancer‐and anti‐ischaemia (stroke or …

Microparticles (MP) are vesicular structures released from cells upon activation, malignant
transformation, stress, or death. MP may be derived from the plasma membrane (shed …

Background Gut homeostasis is central to whole organism health, and its disruption is
associated with a broad range of pathologies. Following damage, complex physiological …

Autophagy is a cell survival process which is related to breaking down and reusing
cytoplasm components. Moreover, autophagy regulates cell death under certain conditions …

Pin1 is a phospho-specific prolyl isomerase that regulates numerous key signaling
molecules and whose deregulation contributes to disease notably cancer. However, since …