Concepts for agonistic targeting of CD40 in immuno-oncology
DM Richards, JP Sefrin, C Gieffers, O Hill… - Human vaccines & …, 2020 - Taylor & Francis
ABSTRACT TNF Receptor Superfamily (TNF-R-SF) signaling is a structurally well-defined
event that requires proper receptor clustering and trimerization. While the TNF-SF ligands …
event that requires proper receptor clustering and trimerization. While the TNF-SF ligands …
FcγRs and their relevance for the activity of anti-CD40 antibodies
I Lang, O Zaitseva, H Wajant - International Journal of Molecular Sciences, 2022 - mdpi.com
Simple Summary Targeting of CD40 with antibodies attracts significant translational interest.
While inhibitory CD40 targeting appears particularly attractive in the field of organ …
While inhibitory CD40 targeting appears particularly attractive in the field of organ …
Cellular Mechanisms Underlying B Cell Abnormalities in Patients With Gain-of-Function Mutations in the PIK3CD Gene
W Wang, Q Min, N Lai, K Csomos, Y Wang… - Frontiers in …, 2022 - frontiersin.org
Background Activated phosphoinositide 3 kinase (PI3K)-delta syndrome (APDS) is an
inborn error of immunity with variable clinical phenotype of immunodeficiency and immune …
inborn error of immunity with variable clinical phenotype of immunodeficiency and immune …
Genetically engineered IgG1 and nanobody oligomers acquire strong intrinsic CD40 agonism
N Hesen, M Anany, A Freidel, M Baker… - …, 2024 - Taylor & Francis
Most anti-CD40 antibodies show robust agonism only upon binding to FcγR+ cells, such as
B cells, macrophages, or DCs, but a few anti-CD40 antibodies display also strong intrinsic …
B cells, macrophages, or DCs, but a few anti-CD40 antibodies display also strong intrinsic …
Intrinsic functional defects in B cells of patients with NFKB2 mutations
Q Min, Y Li, X Wu, M Yu, W Ying, Q Zhou… - Clinical and …, 2024 - academic.oup.com
Mutations in the human nuclear factor-κB2 gene (NFKB2) are associated with common
variable immunodeficiency (CVID) or combined immunodeficiency diseases (CID) …
variable immunodeficiency (CVID) or combined immunodeficiency diseases (CID) …
[HTML][HTML] EAF2 deficiency attenuates autoimmune disease in Faslpr mice by modulating B cell activation and apoptosis
Y Luan, Q Min, R Zhang, Z Wen, X Meng, Z Hu, X Feng… - iScience, 2024 - cell.com
MRL/lpr mice develop systemic lupus erythematosus-like autoimmunity due to defective FAS-
mediated apoptosis. We generated Fas lpr mice deficient in EAF2, a transcription elongation …
mediated apoptosis. We generated Fas lpr mice deficient in EAF2, a transcription elongation …
Emerging concepts regarding pro-and anti tumor properties of B cells in tumor immunity
Y Qin, F Lu, K Lyu, AE Chang, Q Li - Frontiers in Immunology, 2022 - frontiersin.org
Controversial views regarding the roles of B cells in tumor immunity have existed for several
decades. However, more recent studies have focused on its positive properties in antitumor …
decades. However, more recent studies have focused on its positive properties in antitumor …
Therapeutic applications of DNA origami-based programmable nanoparticles
OJY Arnold - 2024 - dspace.mit.edu
DNA origami utilizes the complementary Watson and Crick base pairing of DNA to self-
assemble highly programmable nanoparticles. These nanoparticles have distinct …
assemble highly programmable nanoparticles. These nanoparticles have distinct …
[图书][B] An investigation of the intestinal epithelial damage response to cytokines produced during inflammatory bowel disease and sepsis
FI Ikuomola - 2020 - search.proquest.com
Sepsis is a life-threatening host response to severe systemic infection that can result in multi-
organ dysfunction syndrome (MODS) and organ failure. Globally, there are around 30 …
organ dysfunction syndrome (MODS) and organ failure. Globally, there are around 30 …