Polymeric hydrogels for novel contact lens-based ophthalmic drug delivery systems: A review

L Xinming, C Yingde, AW Lloyd, SV Mikhalovsky… - Contact Lens and …, 2008 - Elsevier
Only about 5% of drugs administrated by eye drops are bioavailable, and currently eye
drops account for more than 90% of all ophthalmic formulations. The bioavailability of …

Excipient–drug interactions in parenteral formulations

MJ Akers - Journal of pharmaceutical sciences, 2002 - Elsevier
Excipients are added to parenteral formulations to enhance or maintain active ingredient
solubility (solubilizers) and/or stability (buffers, antioxidants, chelating agents, cryo‐and …

Soft contact lenses capable of sustained delivery of timolol

C Alvarez-Lorenzo, H Hiratani… - Journal of …, 2002 - Elsevier
The aim of this work was to evaluate the influence of the composition and the application of
an imprinting technique on the loading capability of weakly crosslinked hydroxyethyl …

Timolol uptake and release by imprinted soft contact lenses made of N, N-diethylacrylamide and methacrylic acid

H Hiratani, C Alvarez-Lorenzo - Journal of Controlled Release, 2002 - Elsevier
The aim of this work was to evaluate the utility of molecular imprinting for improving the
loading capability of weakly cross-linked hydrogels, with a view to their use as soft contact …

Hydrogel contact lens for extended delivery of ophthalmic drugs

X Hu, L Hao, H Wang, X Yang, G Zhang… - … Journal of Polymer …, 2011 - Wiley Online Library
Soft contact lenses can improve the bioavailability and prolong the residence time of drugs
and, therefore, are ideal drug carriers for ophthalmic drug delivery. Hydrogels are the …

Permeation through cornea

M Malhotra, DK Majumdar - 2001 - nopr.niscpr.res.in
The permeability of the cornea to drugs is clinically important because it is the major factor
determining the efficacy of topically applied ophthalmic preparations. With this perspective …

Development and characterization of microemulsions for ocular application

A Haβe, S Keipert - European journal of pharmaceutics and …, 1997 - Elsevier
Water-continuous microemulsions for ocular application were developed and the physico-
chemical parameters characterized. These microemulsions have favourable features for …

Drug excipients

H Kalasz, I Antal - Current medicinal chemistry, 2006 - ingentaconnect.com
The therapeutical use of drugs involves the application of dosage forms, serving as carrier
systems together with several excipients to deliver the active ingredient to the site of action …

Influence of irradiation sterilization on polymers used as drug carriers—a review

MB Sintzel, A Merkli, C Tabatabay… - Drug development and …, 1997 - Taylor & Francis
A survey was made of the influence of irradiation sterilization on relevant natural,
semisynthetic, and synthetic polymers used for drug carrier system. The first part of the …

Incorporation of small quantities of surfactants as a way to improve the rheological and diffusional behavior of carbopol gels

R Barreiro-Iglesias, C Alvarez-Lorenzo… - Journal of Controlled …, 2001 - Elsevier
This paper analyzes the effects of Tween 80, Pluronic F-127, sodium dodecylsulfate (SDS),
and benzalkonium chloride on the macro and microviscosity of Carbopol® 934NF (0.25 …