DNA vaccination has suddenly become a favoured strategy for inducing immunity. The
molecular precision offered by gene-based vaccines, together with the facility to include …

DNA vaccines have been widely used in efforts to develop vaccines against various
pathogens as well as for cancer, autoimmune diseases and allergy. DNA vaccines offer …

The unique immunoglobulin (Ig) idiotype on the surface of each B-cell lymphoma represents
an ideal tumor-specific antigen for use as a therapeutic vaccine. We have used an …

The evidence that proteasomes are involved in the processing of cross-presented proteins is
indirect and based on the in vitro use of proteasome inhibitors. It remains, therefore, unclear …

We have developed novel DNA fusion vaccines encoding tumor Ags fused to pathogen-
derived sequences. This strategy activates linked T cell help and, using fragment C of tetnus …

DNA vaccines represent a potentially promising approach for antigen-specific
immunotherapy. Advances in our knowledge of the adaptive immune system have indicated …

A hallmark of the immune system is the ability to ignore self-antigens. In attempts to bypass
normal immune tolerance, a post-translational protein modification was introduced into self …

Self‐tolerance, presumably through lineage‐unbiased elimination of self‐antigen‐specific
lymphocytes (CD4+ T, CD8+ T, and B cells), creates a formidable barrier to cancer …

The Wilms tumor antigen, WT1, is associated with several human cancers, including
leukemia. We evaluated WT1 as an immunotherapeutic target using our proven DNA fusion …

CTLs are thought to be major effectors for clearing viruses in acute infections including
hepatitis B virus (HBV). Persistent HBV infection is characterized by a lack of or a weak CTL …