[HTML][HTML] Natural medicines for the treatment of epilepsy: bioactive components, pharmacology and mechanism

LY He, MB Hu, RL Li, R Zhao, LH Fan, L He… - Frontiers in …, 2021 - frontiersin.org
Epilepsy is a chronic disease that can cause temporary brain dysfunction as a result of
sudden abnormal discharge of the brain neurons. The seizure mechanism of epilepsy is …

Emerging perspectives on mitochondrial dysfunctioning and inflammation in epileptogenesis

S Singh, TG Singh - Inflammation Research, 2021 - Springer
Introduction Mitochondrial dysfunction is a common denominator of neuroinflammation
recognized by neuronal oxidative stress-mediated apoptosis that is well recognized by …

The GluN2B-Trp373 NMDA receptor variant is associated with autism-, epilepsy-related phenotypes and reduces NMDA receptor currents in rats

X Wang, Z Guo, D Mei, Y Zhang, S Zhao, S Hu… - Neurochemical …, 2022 - Springer
Autism spectrum disorder (ASD) is a neurodevelopmental condition with core clinical
features of abnormal communication, social interactions, atypical intelligence, and a higher …

Neuroprotection by tetramethylpyrazine and its synthesized analogues for central nervous system diseases: A review

F Feng, DQ Xu, SJ Yue, YY Chen, YP Tang - Molecular Biology Reports, 2024 - Springer
Background Due to the global increase in aging populations and changes in modern
lifestyles, the prevalence of neurodegenerative diseases, cerebrovascular disorders …

[HTML][HTML] An integrated in vitro human iPSCs-derived neuron and in vivo animal approach for preclinical screening of anti-seizure compounds

C Zhao, B Rollo, MS Javaid, Z Huang, W He… - Journal of Advanced …, 2023 - Elsevier
Introduction One-third of people with epilepsy continue to experience seizures despite
treatment with existing anti-seizure medications (ASMs). The failure of modern ASMs to …

Cadherins and the pathogenesis of epilepsy

C Yang, Y Shi, X Li, L Guan, H Li… - Cell Biochemistry and …, 2022 - Wiley Online Library
Epilepsy is a nervous system disease caused by abnormal discharge of brain neurons,
which is characterized by recurrent seizures. The factors that induce epilepsy include …

[HTML][HTML] Efficacy and safety of Chinese herbal medicine in post-stroke epilepsy: a systematic review and meta-analysis

T Sun, K Wang, L Li, M Yan, J Wu, J Liu - Frontiers in Pharmacology, 2023 - frontiersin.org
Background: Poststroke epilepsy (PSE) is a common complication of strokes that seriously
affects the recovery and quality of life of patients, and effective treatments are needed …

[HTML][HTML] A narrative review on traditional Chinese medicine prescriptions and bioactive components in epilepsy treatment

F Tao, Y Cai, C Deng, Z Chen, Y Shen… - Annals of Translational …, 2023 - ncbi.nlm.nih.gov
Methods We used the terms,“TCM”,“traditional Chinese medicine”,“herbal”,“epilepsy”,“
seizure”, and the name of each prescription and bioactive components in the review to …

The tetramethylpyrazine analogue T-006 alleviates cognitive deficits by inhibition of tau expression and phosphorylation in transgenic mice modeling Alzheimer's …

G Zhang, J Wu, C Huang, J Cheng, Z Su, Z Zhu… - Journal of Molecular …, 2021 - Springer
Abstract T-006, a small-molecule compound derived from tetramethylpyrazine (TMP), has
potential for the treatment of neurological diseases. In order to investigate the effect of T-006 …

Tetramethylpyrazine contributes to the neuroprotection in a rodent epileptic model of pentylenetetrazole-induced kindling

RCSR Danduga, HB Shaik, S Polopalli… - Journal of Pharmacy …, 2023 - academic.oup.com
Objectives In this study, tetramethylpyrazine (TMP) was evaluated for its therapeutic
potential as an alternative therapy for epileptogenesis and its associated comorbidities in …