Most eukaryotic mRNAs are translated in a cap-dependent fashion; however, under stress
conditions, the cap-independent translation driven by internal ribosomal entry sites (IRESs) …

Initiation of translation of most eukaryotic mRNAs commences with 5 end–dependent
recruitment of 40S ribosomal subunits to the mRNA. The 40S subunit carrying the initiator …

Growth-promoting signaling molecules, including the mammalian target of rapamycin
complex 1 (mTORC1), drive the metabolic reprogramming of cancer cells required to …

Translational control of mRNAs is a point of convergence for many oncogenic signals
through which cancer cells tune protein expression in tumorigenesis. Cancer cells rely on …

Initiation of translation in eukaryotic cells can occur by two distinct mechanisms, cap-
dependent scanning and internal ribosome entry. The latter mechanism requires the …

The cell has many ways to regulate the production of proteins. One mechanism is through
the changes to the machinery of translation initiation. These alterations favor the translation …

Prior work demonstrates that AKT activity regulates sensitivity of cells to G 1 arrest induced
by mammalian target of rapamycin (mTOR) inhibitors such as rapamycin and CCI-779. To …

The vast majority of eukaryotic messenger RNAs (mRNAs) initiate translation through a
canonical, cap-dependent mechanism requiring a free 5′ end and 5′ cap and several …

Internal ribosome entry sites/segments (IRESs) were first discovered over 20 years ago in
picornaviruses, followed by the discovery of two other types of IRES in hepatitis C virus …

Although studies on viral gene expression were essential for the discovery of internal
ribosome entry sites (IRESs), it is becoming increasingly clear that IRES activities are …