Covering: up to 2020 The National Cancer Institute of the United States (NCI) has initiated a
Cancer Moonshot program entitled the NCI Program for Natural Product Discovery. As part …

Sesquiterpenes belong to the largest group of plant secondary metabolites, which consist of
three isoprene building units. These compounds are widely distributed in various …

Chromosomal translocation results in development of an Ewing sarcoma breakpoint region
1‐Friend leukemia integration 1 (EWS–FLI1) fusion oncogene in the majority of Ewing …

The ETS family of proteins consists of 28 transcription factors, many of which have been
implicated in development and progression of a variety of cancers. While one family …

While sarcomas account for approximately 1% of malignant tumors of adults, they are
particularly more common in children and adolescents affected by cancer. In contrast to …

Aims Transient receptor potential canonical 5 (TRPC5) channels are redox-sensitive cation-
permeable channels involved in temperature and mechanical sensation. Increased …

EWS/FLI is the defining mutation of Ewing sarcoma. This oncogene drives malignant
transformation and progression and occurs in a genetic background characterized by few …

The driving roles of fusion genes during tumorigenesis have been recognized for decades,
with efficacies demonstrated in clinical diagnosis and targeted therapy. With advances in …

Ewing's sarcoma (ES) is a highly aggressive and metastatic tumor in children and young
adults caused by a chromosomal fusion between the Ewing sarcoma breakpoint region 1 …

Ewing sarcoma is a pediatric bone and soft tissue tumor treated with chemotherapy,
radiation, and surgery. Despite intensive multimodality therapy,~ 50% patients eventually …