Esophageal adenocarcinoma develops through a cascade of cellular changes that shares
similarities to the etiology of Helicobacter pylori-associated intestinal-type gastric …

Simple Summary This article delves into the mounting impact of the microbiome on
gastroesophageal cancer. Investigating its connection to immunotherapy, this study explores …

Barrett's oesophagus is a precursor of oesophageal adenocarcinoma. In this common
condition, squamous epithelium in the oesophagus is replaced by columnar epithelium in …

Columnar metaplasia of the esophagus is the main risk factor for esophageal
adenocarcinoma. There is a lack of evidence to demonstrate that esophageal progenitors …

Esophageal cancer (ESCA) is the seventh most frequent and deadly neoplasm. Due to the
lack of early diagnosis and high invasion/metastasis, the prognosis of ESCA remains very …

Background & Aims MicroRNA (miRNA) is highly stable in biospecimens and provides
tissue-specific profiles, making it a useful biomarker of carcinogenesis. We aimed to …

Barrett's esophagus (BE) is a well-known precancerous condition of esophageal
adenocarcinoma. However, the immune cells and immune related genes involved in BE …

Although Barrett's metaplasia of the esophagus (BE) is the only known precursor lesion to
esophageal adenocarcinomas (EACs), drivers of cellular transformation in BE remain …

TGFβ signaling has been implicated in the metaplasia from squamous epithelia to Barrett's
esophagus and, ultimately, esophageal adenocarcinoma. The role of the family member …

Background & Aims The transcription factor GATA4 is broadly expressed in nascent foregut
endoderm. As development progresses, GATA4 is lost in the domain giving rise to the …