Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment

G Huang, F Li, X Zhao, Y Ma, Y Li, M Lin, G Jin… - Chemical …, 2017 - ACS Publications
The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Growth factor engineering strategies for regenerative medicine applications

X Ren, M Zhao, B Lash, MM Martino… - … in bioengineering and …, 2020 - frontiersin.org
Growth factors are critical molecules for tissue repair and regeneration. Therefore,
recombinant growth factors have raised a lot of hope for regenerative medicine applications …

Materials roles for promoting angiogenesis in tissue regeneration

JH Lee, P Parthiban, GZ Jin, JC Knowles… - Progress in Materials …, 2021 - Elsevier
Enabling angiogenesis is critical for the success of tissue repair therapies and the fate of
tissue-engineered constructs. Although many biochemical signaling molecules have been …

Bioactive materials for bone regeneration: biomolecules and delivery systems

A Szwed-Georgiou, P Płociński… - ACS Biomaterials …, 2023 - ACS Publications
Novel tissue regeneration strategies are constantly being developed worldwide. Research
on bone regeneration is noteworthy, as many promising new approaches have been …

Vascularization is the key challenge in tissue engineering

EC Novosel, C Kleinhans, PJ Kluger - Advanced drug delivery reviews, 2011 - Elsevier
The main limitation in engineering in vitro tissues is the lack of a sufficient blood vessel
system—the vascularization. In vivo almost all tissues are supplied by these endothelial cell …

An overview of the suitability of hydrogel-forming polymers for extrusion-based 3D-printing

DM Kirchmajer, R Gorkin Iii - Journal of Materials Chemistry B, 2015 - pubs.rsc.org
This review evaluates hydrogel-forming polymers that are suitable for soft tissue engineering
with a focus on materials that can be fabricated using additive manufacturing (3D-printing) …

From arteries to capillaries: approaches to engineering human vasculature

S Fleischer, DN Tavakol… - Advanced functional …, 2020 - Wiley Online Library
From microscaled capillaries to millimeter‐sized vessels, human vasculature spans multiple
scales and cell types. The convergence of bioengineering, materials science, and stem cell …

Hydrogel scaffolds as in vitro models to study fibroblast activation in wound healing and disease

ME Smithmyer, LA Sawicki, AM Kloxin - Biomaterials science, 2014 - pubs.rsc.org
Wound healing results from complex signaling between cells and their environment in
response to injury. Fibroblasts residing within the extracellular matrix (ECM) of various …

IGF‐1 promotes angiogenesis in endothelial cells/adipose‐derived stem cells co‐culture system with activation of PI 3K/Akt signal pathway

S Lin, Q Zhang, X Shao, T Zhang, C Xue, S Shi… - Cell …, 2017 - Wiley Online Library
Objectives The aim of this study was to investigate the role of insulin‐like growth factor‐1
(IGF‐1) and crosstalk between endothelial cells (EC s) and adipose‐derived stem cells …

Bioactive factor delivery strategies from engineered polymer hydrogels for therapeutic medicine

MK Nguyen, E Alsberg - Progress in polymer science, 2014 - Elsevier
Polymer hydrogels have been widely explored as therapeutic delivery matrices because of
their ability to present sustained, localized and controlled release of bioactive factors …