Damage or loss of brain cells and impaired neurochemistry, neurogenesis, and synaptic and
nonsynaptic plasticity of the brain lead to dementia in neurodegenerative diseases, such as …

Nowadays, nutraceuticals are being incorporated into functional foods or used as
supplements with nonpharmacological approaches in the prevention and management of …

Adenosine signals through four distinct G protein-coupled receptors that are located at
various synapses, cell types and brain areas. Through them, adenosine regulates …

Alzheimer's disease (AD) is the most prevalent kind of dementia with roughly 135 million
cases expected in the world by 2050. Unfortunately, current medications for the treatment of …

Background: Limited and conflicting evidence exists for the associations between tea,
coffee, and caffeine intake and risk of dementia and Alzheimer's disease (AD). This meta …

In this review, we discuss the recent knowledge regarding the epigenetic effects of coffee
extract and the three essential active ingredients in coffee (caffeine, chlorogenic acid, and …

Early pathological upregulation of adenosine A2A receptors (A2ARs), one of the caffeine
targets, by neurons is thought to be involved in the development of synaptic and memory …

Caffeine consumption outcomes on Amyotrophic Lateral Sclerosis (ALS) including
progression, survival and cognition remain poorly defined and may depend on its …

Aims: Caffeine possesses potent antioxidant, anti-inflammatory and anti-apoptotic activities
against a variety of neurodegenerative diseases, including Alzheimer's disease (AD) and …

Caffeine is one of the most popular consumed psychostimulants that mitigates several
neurodegenerative diseases. Nevertheless, the roles and molecular mechanisms of caffeine …