Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA
modification, histone modification, RNA modification, chromatin remodeling, and non-coding …

Simple Summary Uveal melanoma is the most common primary intraocular malignancy in
adults. Although it can be controlled locally, half of the patients still develop metastases. To …

Preclinical studies have suggested that epigenetic therapy could enhance immunogenicity
of cancer cells. We report the results of the PEMDAC phase 2 clinical trial (n= 29; …

Chemotherapy, surgery, and radiation are accepted as the preferred treatment modalities
against cancer, but in recent years the use of immunotherapeutic approaches has gained …

Novel treatment regimens are required for castration-resistant prostate cancers (CRPCs)
that become unresponsive to standard treatments, such as docetaxel and enzalutamide …

Uveal melanoma (UM) and retinoblastoma (RB), which cause blindness and even death,
are the most frequently observed primary intraocular malignancies in adults and children …

Melanoma is an aggressive malignant tumor, arising more commonly on the skin, while it
can also occur on mucosal surfaces and the uveal tract of the eye. In the context of the …

Simple Summary The large amount of knowledge regarding epigenetic pathways has
opened a broad range of treatments that provide hope for adult patients with highly …

Simple Summary Uveal melanoma is the most common primary intraocular malignancy in
adults. Unfortunately, metastasis develops in up to 50% of cases and outcomes are poor for …

Simple Summary Around 50% of patients with uveal melanoma (UM) still develop metastatic
disease. Despite recent advances in the diagnosis and prognosis of UM, improvements in …