The functional and clinical roles of liquid biopsy in patient-derived models

Z Zhu, E Hu, H Shen, J Tan, S Zeng - Journal of Hematology & Oncology, 2023 - Springer
The liquid biopsy includes the detection of circulating tumor cells (CTCs) and CTC clusters
in blood, as well as the detection of, cell-free DNA (cfDNA)/circulating tumor DNA (ctDNA) …

Next‐Generation Preclinical Functional Testing Models in Cancer Precision Medicine: CTC‐Derived Organoids

L Huang, Y Xu, N Wang, K Yi, X Xi, H Si… - Small …, 2024 - Wiley Online Library
Basic and clinical cancer research requires tumor models that consistently recapitulate the
characteristics of prima tumors. As ex vivo 3D cultures of patient tumor cells, patient‐derived …

Tumor organoids: applications in cancer modeling and potentials in precision medicine

H Xu, D Jiao, A Liu, K Wu - Journal of hematology & oncology, 2022 - Springer
Cancer is a top-ranked life-threatening disease with intratumor heterogeneity. Tumor
heterogeneity is associated with metastasis, relapse, and therapy resistance. These factors …

Targeting alternative splicing in cancer immunotherapy

N Han, Z Liu - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
Tumor immunotherapy has made great progress in cancer treatment but still faces several
challenges, such as a limited number of targetable antigens and varying responses among …

[HTML][HTML] Exploring tumor organoids for cancer treatment

H Jin, Q Yang, J Yang, F Wang, J Feng, L Lei, M Dai - APL Materials, 2024 - pubs.aip.org
As a life-threatening chronic disease, cancer is characterized by tumor heterogeneity. This
heterogeneity is associated with factors that lead to treatment failure and poor prognosis …

Identification of Common Liver Metabolites of the Natural Bioactive Compound Erinacine A, Purified from Hericium erinaceus Mycelium

YH Kuo, TW Lin, JY Lin, YW Chen, TJ Li, CC Chen - Applied Sciences, 2022 - mdpi.com
Metabolite identification, in the early stage, for compound discovery is necessary to assess
the knowledge for the pharmaceutical improvement of drug safety and efficacy. Even if the …

Hepatoprotective effect of Antrodia Cinnamomea mycelia extract in subhealth Japanese adults: a randomized, double-blind, placebo-controlled clinical study

CY Ho, CM Kuan, PK Hsu - Journal of Dietary Supplements, 2023 - Taylor & Francis
Antrodia cinnamomea, a unique Taiwanese fungus (mushroom), has demonstrated the
hepatoprotective activities in animals with liver injury. Nevertheless, there are few studies …

Application of Drug Testing Platforms in Circulating Tumor Cells and Validation of a Patient-Derived Xenograft Mouse Model in Patient with Primary Intracranial …

ML Liang, TC Yeh, MH Huang, PS Wu, SP Wu… - Diagnostics, 2023 - mdpi.com
Primary intracranial ependymoma is a challenging tumor to treat despite the availability of
multidisciplinary therapeutic modalities, including surgical resection, radiotherapy, and …

Enumeration and Characterization of Circulating Tumor Cells in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization

ML Espejo-Cruz, S González-Rubio, JJ Espejo… - International Journal of …, 2023 - mdpi.com
Circulating tumor cells (CTCs), and particularly circulating cancer stem cells (cCSC), are
prognostic biomarkers for different malignancies and may be detected using liquid biopsies …