β2 integrins are heterodimeric surface receptors composed of a variable α (CD11a-CD11d)
and a constant β (CD18) subunit and are specifically expressed by leukocytes. The α …

Integrins are a family of cell surface receptors crucial to fundamental cellular functions such
as adhesion, signaling, and viability, deeply involved in a variety of diseases, including the …

Although checkpoint immunotherapies have revolutionized the treatment of cancer, not all
tumor types have seen substantial benefit. Pancreatic ductal adenocarcinoma (PDAC) is a …

Acute Respiratory Distress Syndrome (ARDS) is a clinically severe respiratory disease that
causes severe medical and economic burden. To improve therapeutic efficacy, effectively …

Resistance to immune checkpoint inhibitors (ICI) and other anticancer therapies is often
associated with the accumulation of myeloid-derived suppressor cells (MDSCs) and tumor …

Background & Aims Acetaminophen (APAP)-induced liver injury is coupled with activation of
the blood coagulation cascade and fibrin (ogen) accumulation within APAP-injured livers of …

Background Integrin αM (CD11b), which is encoded by the Integrin Subunit Alpha M
(ITGAM) gene, is not only a surface marker of monocytes but also an essential adhesion …

Aspergillus fumigatus is the most important mould pathogen in immunosuppressed patients.
Suboptimal clearance of inhaled spores results in the colonisation of the lung airways by …

Pancreatic cancer is a devastating malignancy with minimal treatment options. Standard‐of‐
care therapy, including surgery and chemotherapy, is unsatisfactory, and therapies …

Neutrophils are important innate immune cells that respond during inflammation and
infection. These migratory cells utilize β2-integrin cell surface receptors to move out of the …