FBXW7 and human tumors: mechanisms of drug resistance and potential therapeutic strategies
W Wang, K Jiang, X Liu, J Li, W Zhou… - Frontiers in …, 2023 - frontiersin.org
Drug therapy, including chemotherapy, targeted therapy, immunotherapy, and endocrine
therapy, stands as the foremost therapeutic approach for contemporary human …
therapy, stands as the foremost therapeutic approach for contemporary human …
Molecular insights and clinical implications for the tumor suppressor role of SCFFBXW7 E3 ubiquitin ligase
FBXW7 is one of the most well-characterized F-box proteins, serving as substrate receptor
subunit of SKP1-CUL1-F-box (SCF) E3 ligase complexes. SCF FBXW7 is responsible for the …
subunit of SKP1-CUL1-F-box (SCF) E3 ligase complexes. SCF FBXW7 is responsible for the …
DYRK2 promotes chemosensitivity via p53‐mediated apoptosis after DNA damage in colorectal cancer
Y Takano, S Yogosawa, Y Imaizumi… - Cancer …, 2023 - Wiley Online Library
Dual‐specificity tyrosine‐regulated kinase 2 (DYRK2) is a protein kinase that
phosphorylates p53‐Ser46 and induces apoptosis in response to DNA damage. However …
phosphorylates p53‐Ser46 and induces apoptosis in response to DNA damage. However …
An impaired ubiquitin-proteasome system increases APOBEC3A abundance
M Coxon, MA Dennis, A Dananberg, CD Collins… - NAR …, 2023 - academic.oup.com
Abstract Apolipoprotein B messenger RNA (mRNA) editing enzyme, catalytic polypeptide-
like (APOBEC) cytidine deaminases cause genetic instability during cancer development …
like (APOBEC) cytidine deaminases cause genetic instability during cancer development …
The HTLV-I oncoprotein Tax inactivates the tumor suppressor FBXW7
F-box and WD repeat domain containing 7 (FBXW7), a critical tumor suppressor of human
cancers, is frequently mutated or epigenetically suppressed. Loss of FBXW7 functions is …
cancers, is frequently mutated or epigenetically suppressed. Loss of FBXW7 functions is …
Didymin ameliorates ulcerative colitis-associated secondary liver damage by facilitating Notch1 degradation
Q Lv, J Wang, H Yang, X Chen, Y Zhang, G Ji, L Hu… - Phytomedicine, 2024 - Elsevier
Background Didymin is a dietary flavonoid originally discovered by our group as a potent
anti-ulcerative colitis (UC) agent. However, whether didymin plays a protective role in UC …
anti-ulcerative colitis (UC) agent. However, whether didymin plays a protective role in UC …
[HTML][HTML] DataXflow: Synergizing data-driven modeling with best parameter fit and optimal control–An efficient data analysis for cancer research
SAW Crouch, J Krause, T Dandekar… - Computational and …, 2024 - Elsevier
Building data-driven models is an effective strategy for information extraction from empirical
data. Adapting model parameters specifically to data with a best fitting approach encodes …
data. Adapting model parameters specifically to data with a best fitting approach encodes …
Copy number variants at 4q31.3 affecting the regulatory region of FBXW7 associated with neurodevelopmental delay
W Zhou, C Wang, L Fu, W Shi, A Zhang, Z Jia… - Clinical …, 2024 - Wiley Online Library
Emerging research has demonstrated that genomic alterations disrupting topologically
associated domains (TADs) and chromatin interactions underlie the pathogenic …
associated domains (TADs) and chromatin interactions underlie the pathogenic …
CUL1 exacerbates glucocorticoid-induced osteoporosis by enhancing ASAP1 ubiquitination
J Wu, W Ren, J Liu, X Bai - Hormones, 2024 - Springer
Background Glucocorticoid-induced osteoporosis is a leading secondary cause of
osteoporosis. Cullin-1 (CUL1) levels are abnormally elevated in patients with osteoporosis …
osteoporosis. Cullin-1 (CUL1) levels are abnormally elevated in patients with osteoporosis …