Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity

B Fromenty, D Pessayre - Pharmacology & therapeutics, 1995 - Elsevier
Severe and prolonged impairment of mitochondrial β-oxidation leads to microvesicular
steatosis, and, in severe forms, to liver failure, coma and death. Impairment of mitochondrial …

Toward improved anti-HIV chemotherapy: therapeutic strategies for intervention with HIV infections

E De Clercq - Journal of medicinal chemistry, 1995 - ACS Publications
The anti-HIV chemotherapy era started a decade ago when suramin was found to protect
human T lympho-cytes against the infectivity and cytopathicity of human immunodeficiency …

Molecular targets for AIDS therapy

H Mitsuya, R Yarchoan, S Broder - Science, 1990 - science.org
The development of antiretroviral therapy against acquired immunodeficiency syndrome
(AIDS) has been an intense research effort since the discovery of the causative agent …

Drug induced acute pancreatitis: incidence and severity.

PG Lankisch, M Dröge, F Gottesleben - Gut, 1995 - gut.bmj.com
To determine the incidence and severity of drug induced acute pancreatitis, data from 45
German centres of gastroenterology were evaluated. Among 1613 patients treated for acute …

[图书][B] AIDS epidemiology: a quantitative approach

R Brookmeyer, MH Gail - 1994 - books.google.com
AIDS has appeared in more than 130 countries, and over 100,000 cases of AIDS have been
reported in the US alone. More and more, the public will be depending on statisticians to …

CD4+ Lymphocyte Cell Enumeration for Prediction of Clinical Course of Human Immunodeficiency Virus Disease: A Review

DS Stein, JA Korvick, SH Vermund - Journal of Infectious …, 1992 - academic.oup.com
Over the last 10 years the appreciation of the full breadth of the spectrum of human
immunodeficiency virus (HIV) infection has gradually increased; it is now known that AIDS …

Synthesis, chromatographic resolution, and anti-human immunodeficiency virus activity of (±)-calanolide A and its enantiomers

MT Flavin, JD Rizzo, A Khilevich… - Journal of Medicinal …, 1996 - ACS Publications
The anti-HIV agent (±)-calanolide A (1) has been synthesized in a five-step approach
starting with phloroglucinol [→ 5→ 6→ 11→ 18→(±)-1], which includes Pechmann reaction …

Inhibitory effects of egyptian folk medicines oh human immunodeficiency virus (HIV) reverse transcriptase

S EL-MEKKAWY, MR MESELHY… - Chemical and …, 1995 - jstage.jst.go.jp
抄録 Extracts of 41 medicinal plants used in Egyptian folk medicine were screened for their
inhibitory effects on human immunodeficiency virus-1 reverse transcriptase. The extracts of …

Peripheral neuropathy and antiretroviral drugs

MC Dalakas - Journal of the peripheral nervous system, 2001 - Wiley Online Library
Patients treated with nucleoside analogue reverse transcriptase inhibitors (NRTIs) develop a
varying degree of myopathy or neuropathy after long‐term therapy. Zidovudine (AZT) causes …

A phase II trial of nerve growth factor for sensory neuropathy associated with HIV infection

JC McArthur, C Yiannoutsos, DM Simpson… - Neurology, 2000 - AAN Enterprises
Objective: To evaluate the safety and efficacy of recombinant human nerve growth factor
(rhNGF) in HIV-associated sensory neuropathy (SN) within a multicenter, placebo …