Dopamine: functions, signaling, and association with neurological diseases
The dopaminergic system plays important roles in neuromodulation, such as motor control,
motivation, reward, cognitive function, maternal, and reproductive behaviors. Dopamine is a …
motivation, reward, cognitive function, maternal, and reproductive behaviors. Dopamine is a …
Antipsychotic drug—Aripiprazole against schizophrenia, its therapeutic and metabolic effects associated with gene polymorphisms
A Stelmach, K Guzek, A Rożnowska, I Najbar… - Pharmacological …, 2023 - Springer
Second-generation antipsychotics are widely used for the treatment of schizophrenia.
Aripiprazole (ARI) is classified as a third-generation antipsychotic drug with a high affinity for …
Aripiprazole (ARI) is classified as a third-generation antipsychotic drug with a high affinity for …
Aripiprazole, a drug that displays partial agonism and functional selectivity
EW Tuplin, MR Holahan - Current neuropharmacology, 2017 - ingentaconnect.com
Background: The treatment of schizophrenia is challenging due to the wide range of
symptoms (positive, negative, cognitive) associated with the disease. Typical antipsychotics …
symptoms (positive, negative, cognitive) associated with the disease. Typical antipsychotics …
[HTML][HTML] The treatment of adult bipolar disorder with aripiprazole: a systematic review
A Muneer - Cureus, 2016 - ncbi.nlm.nih.gov
Bipolar disorder is characterized by exacerbations of opposite mood polarity, ranging from
manic to major depressive episodes. In the current nosological system of the Diagnostic and …
manic to major depressive episodes. In the current nosological system of the Diagnostic and …
Comprehensive pathway analyses of schizophrenia risk loci point to dysfunctional postsynaptic signaling
D Schijven, D Kofink, V Tragante, M Verkerke… - Schizophrenia …, 2018 - Elsevier
Large-scale genome-wide association studies (GWAS) have implicated many low-
penetrance loci in schizophrenia. However, its pathological mechanisms are poorly …
penetrance loci in schizophrenia. However, its pathological mechanisms are poorly …
Increased risk for developing gambling disorder under the treatment with pramipexole, ropinirole, and aripiprazole: A nationwide register study in Sweden
M Wolfschlag, A Håkansson - PloS one, 2021 - journals.plos.org
Gambling Disorder (GD) has recently been reclassified from an impulse-control disorder to a
behavioural addiction and, as in other addictive disorders, the dopaminergic reward system …
behavioural addiction and, as in other addictive disorders, the dopaminergic reward system …
Dopamine D1- and D2-like receptors oppositely regulate lifespan via a dietary restriction mechanism in Caenorhabditis elegans
Background Despite recent progress in understanding the molecular mechanisms
regulating aging and lifespan, and the pathways involved being conserved in different …
regulating aging and lifespan, and the pathways involved being conserved in different …
Chronic administration of aripiprazole activates GSK3β-dependent signalling pathways and up-regulates GABAA receptor expression and CREB1 activity in rats
Aripiprazole is a D2-like receptor (D2R) partial agonist with a favourable clinical profile.
Previous investigations indicated that acute and short-term administration of aripiprazole …
Previous investigations indicated that acute and short-term administration of aripiprazole …
Aripiprazole attenuates the medial prefrontal cortex morphological and biochemical alterations in rats with neonatal ventral hippocampus lesion
GD Flores-Gómez, DJ Apam-Castillejos… - Journal of Chemical …, 2023 - Elsevier
Schizophrenia is a neurodevelopmental disorder characterized by a loss of dendritic spines
in the medial prefrontal cortex (mPFC). Multiple subclinical and clinical studies have …
in the medial prefrontal cortex (mPFC). Multiple subclinical and clinical studies have …
Aripiprazole Increases the PKA Signalling and Expression of the GABAA Receptor and CREB1 in the Nucleus Accumbens of Rats
The GABA A receptor is implicated in the pathophysiology of schizophrenia and regulated
by PKA signalling. Current antipsychotics bind with D 2-like receptors, but not the GABA A …
by PKA signalling. Current antipsychotics bind with D 2-like receptors, but not the GABA A …