With the progress of the aging population, bone-related diseases such as osteoporosis and
osteoarthritis have become urgent problems. Recent studies have demonstrated the …

Particulate pollution is a global risk factor that seriously threatens human health. Fine
particles (FPs) and ultrafine particles (UFPs) have small particle diameters and large specific …

Imbalance of bone homeostasis induces bone degenerative diseases such as osteoporosis.
Hedgehog (Hh) signaling plays critical roles in regulating the development of limb and joint …

MALAT1, one of the few highly conserved nuclear long noncoding RNAs (lncRNAs), is
abundantly expressed in normal tissues. Previously, targeted inactivation and genetic …

Ethnopharmacological relevance Wear particle-induced inflammatory osteoclast activation
is a master contributor to periprosthetic osteolysis, which can cause pathological bone loss …

Estrogen receptors alpha (ERα), a member of the nuclear receptor protein family, was found
to play an important role in maintaining bone mass. Its downstream signaling proteins such …

Rationale: Bone homeostasis is maintained by a balanced interplay of osteoblasts and
osteoclasts. Osteoclasts are derived from monocyte/macrophage lineage. Major vault …

The disruption of bone homeostasis with the decrease in osteoblastic bone formation and
facilitated osteoclastic bone resorption is the leading cause of periprosthetic osteolysis …

Background Excessive osteoclast formation disrupts bone homeostasis, thereby significantly
contributing to pathological bone loss associated with a variety of diseases. Protein S …

Bone metabolic homeostasis is largely dependent on the dynamic balance between
osteoblasts and osteoclasts. MicroRNAs (miRNAs) play critical roles in regulating bone …