Corneal transplantation is the only option to cure corneal opacities. However, there is an
imbalance between supply and demand of corneal tissues in the world. To solve the …

Progressive corneal endothelial disease eventually leads to corneal edema and vision loss
due to the limited regenerative capacity of the corneal endothelium in vivo and is a major …

Bulk RNA sequencing of a tissue captures the gene expression profile from all cell types
combined. Single-cell RNA sequencing identifies discrete cell-signatures based on …

This study aimed to investigate the underlying mechanisms of corneal endothelial cells
(CECs) differentiation and identify the extracellular matrix (ECM) compositions using …

Purpose: To investigate the effect of COL8A2 repression on corneal endothelial cells (CECs)
in vitro and in vivo. Methods: Cultured human CECs (hCECs) were transfected with COL8A2 …

To expand multi-potent progenitors from human trabecular meshwork (TM), we have created
a new optimized method on two-dimensional (2D) followed by three–dimensional (3D) …

Background The aim of this study is to compare the three previously applied, conventional
porcine corneal decellularization methods and to demonstrate the importance of preserving …

Limbal niche cells located in the limbal Palisades of Vogt are mesenchymal stem cells that
reside next to limbal basal epithelial cells. Limbal niche cells are progenitors that express …

Corneal opacity is one of the leading causes of severe vision impairment. Corneal
transplantation is the dominant therapy for irreversible corneal blindness. However, there is …

Introduction Corneal endothelial dysfunction results in cornea opacity, damaging
sightedness, and affecting quality of life. A corneal transplant is the current effective …