Translational applications of hydrogels

S Correa, AK Grosskopf, H Lopez Hernandez… - Chemical …, 2021 - ACS Publications
Advances in hydrogel technology have unlocked unique and valuable capabilities that are
being applied to a diverse set of translational applications. Hydrogels perform functions …

Recent advances of self-assembling peptide-based hydrogels for biomedical applications

J Li, R Xing, S Bai, X Yan - Soft matter, 2019 - pubs.rsc.org
Peptide-based hydrogels have been proven to be preeminent biomedical materials due to
their high water content, tunable mechanical stability, great biocompatibility and excellent …

Self-assembling paclitaxel-mediated stimulation of tumor-associated macrophages for postoperative treatment of glioblastoma

F Wang, Q Huang, H Su, M Sun… - Proceedings of the …, 2023 - National Acad Sciences
The unique cancer-associated immunosuppression in brain, combined with a paucity of
infiltrating T cells, contributes to the low response rate and poor treatment outcomes of T cell …

Design and applications of man-made biomimetic fibrillar hydrogels

E Prince, E Kumacheva - Nature Reviews Materials, 2019 - nature.com
Many extracellular matrices (ECMs) have a filamentous architecture, which influences cell
growth and phenotype and imparts tissues with specific properties. Man-made fibrillar …

Bioengineering strategies to accelerate stem cell therapeutics

CM Madl, SC Heilshorn, HM Blau - Nature, 2018 - nature.com
Although only a few stem cell-based therapies are currently available to patients, stem cells
hold tremendous regenerative potential, and several exciting clinical applications are on the …

Exploiting the role of nanoparticle shape in enhancing hydrogel adhesive and mechanical properties

MC Arno, M Inam, AC Weems, Z Li, ALA Binch… - Nature …, 2020 - nature.com
The ability to control nanostructure shape and dimensions presents opportunities to design
materials in which their macroscopic properties are dependent upon the nature of the …

Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons

Z Álvarez, JA Ortega, K Sato, IR Sasselli… - Cell stem cell, 2023 - cell.com
Human induced pluripotent stem cell (hiPSC) technologies offer a unique resource for
modeling neurological diseases. However, iPSC models are fraught with technical …

Peptide supramolecular materials for therapeutics

K Sato, MP Hendricks, LC Palmer… - Chemical Society Reviews, 2018 - pubs.rsc.org
Supramolecular assembly of peptide-based monomers into nanostructures offers many
promising applications in advanced therapies. In this Tutorial Review, we introduce …

Orienting muscle stem cells for regeneration in homeostasis, aging, and disease

P Feige, CE Brun, M Ritso, MA Rudnicki - Cell stem cell, 2018 - cell.com
Muscle stem cells, or satellite cells, are required for skeletal muscle maintenance, growth,
and repair. Following satellite cell activation, several factors drive asymmetric cell division to …

Bioinks and bioprinting strategies for skeletal muscle tissue engineering

M Samandari, J Quint… - Advanced …, 2022 - Wiley Online Library
Skeletal muscles play important roles in critical body functions and their injury or disease
can lead to limitation of mobility and loss of independence. Current treatments result in …