Characterizing the adult zebrafish model of Parkinson's disease: a systematic review of dynamic changes in behavior and physiology post-MPTP administration

K Razali, J Kumar, WMY Mohamed - Frontiers in Neuroscience, 2024 - frontiersin.org
Introduction Adult zebrafish are increasingly used in Parkinson's disease (PD) research due
to their well-characterized dopaminergic system. Among the toxin-based models, the …

Assessment of CRISPRa-mediated gdnf overexpression in an In vitro Parkinson's disease model

P Guzmán-Sastoque, S Sotelo, NP Esmeral… - … in Bioengineering and …, 2024 - frontiersin.org
Introduction Parkinson's disease (PD) presents a significant challenge in medical science,
as current treatments are limited to symptom management and often carry significant side …

Promoting the welfare of animals utilized in neuroscience research

T Zhang, NN Zhang, R Feng, H Wang, F Bi, S Wang - Brain‐X, 2024 - Wiley Online Library
The safeguarding of animal welfare holds a deep‐rooted history within public institutions
and legislative structures, with the objective of enhancing the comfort and overall wellbeing …

Neuroprotective effects of Neurotrophin-3 in MPTP-induced zebrafish Parkinson's disease model

NA Omar, J Kumar, SL Teoh - Frontiers in Pharmacology, 2023 - frontiersin.org
Introduction: Neurotrophin-3 (NT3) is a neuroprotective growth factor that induces the
development, maintenance and survival of neurons. This study aims to localize NT3 …

Stat3 mediates Fyn kinase-driven dopaminergic neurodegeneration and microglia activation

S Siddiqui, F Liu, AG Kanthasamy… - Disease Models & …, 2024 - journals.biologists.com
The Alzheimer's disease and Parkinson's disease risk locus FYN kinase is implicated in
neurodegeneration and inflammatory signaling. To investigate in vivo mechanisms of Fyn …

[HTML][HTML] Intraperitoneal Injection of the Porphyromonas gingivalis Outer Membrane Vesicle (OMV) Stimulated Expressions of Neuroinflammatory Markers and …

M Adewoyin, A Hamarsha, R Akinsola, SL Teoh… - International Journal of …, 2024 - mdpi.com
Porphyromonas gingivalis is the major pathogenic bacteria found in the subgingival plaque
of patients with periodontitis, which leads to neuroinflammation. The bacteria destroy …

1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-treated adult zebrafish as a model for Parkinson's Disease

E Bagwell, M Shin, N Henkel, D Migliaccio, C Peng… - Neuroscience …, 2024 - Elsevier
Dopamine (DA) is a catecholamine neurotransmitter that works to regulate cognitive
functions. Patients affected by Parkinson's Disease (PD) experience a loss of dopaminergic …

Benincasa hispida Alleviates Stress and Anxiety in a Zebrafish (Danio rerio) Model

NK Lakshmanagowda, N Sagar, R Puttasiddaiah… - Life, 2024 - mdpi.com
The Ayurvedic medical system uses fruits of the Benincasa hispida plant to treat mental
diseases, including schizophrenia. The goal of the current study was to assess the aqueous …

[HTML][HTML] Morpho-Anatomical Degeneration of Dopaminergic Neurons in Adult Zebrafish Brain after Exposure to Nickel

P Cacialli, S Ricci, M Lazzari, V Franceschini - Fishes, 2024 - mdpi.com
Chronic exposure to heavy metals has been widely demonstrated to induce pathological
features in different tissues and, in particular, in the central nervous system. Specific …

Size-dependent harvest mortality indirectly affects boldness, feeding rate, and behaviour-linked gene expression in a decade-long selection experiment on guppies

B Diaz Pauli, V Tronci, AS Gomes, M Heino - bioRxiv, 2023 - biorxiv.org
Fisheries-induced mortality is size-selective, commonly targeting large individuals, which
leads to evolution towards smaller size and early maturation. However, little is known on …