Next-generation proteomics: towards an integrative view of proteome dynamics
Next-generation sequencing allows the analysis of genomes, including those representing
disease states. However, the causes of most disorders are multifactorial, and systems-level …
disease states. However, the causes of most disorders are multifactorial, and systems-level …
Target of rapamycin (TOR) in nutrient signaling and growth control
Abstract TOR (T arget O f R apamycin) is a highly conserved protein kinase that is important
in both fundamental and clinical biology. In fundamental biology, TOR is a nutrient-sensitive …
in both fundamental and clinical biology. In fundamental biology, TOR is a nutrient-sensitive …
The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions
R Oughtred, J Rust, C Chang, BJ Breitkreutz… - Protein …, 2021 - Wiley Online Library
Abstract The BioGRID (Biological General Repository for Interaction Datasets, thebiogrid.
org) is an open‐access database resource that houses manually curated protein and …
org) is an open‐access database resource that houses manually curated protein and …
The BioGRID interaction database: 2019 update
R Oughtred, C Stark, BJ Breitkreutz, J Rust… - Nucleic acids …, 2019 - academic.oup.com
Abstract The Biological General Repository for Interaction Datasets (BioGRID:
https://thebiogrid. org) is an open access database dedicated to the curation and archival …
https://thebiogrid. org) is an open access database dedicated to the curation and archival …
Optimization of experimental parameters in data-independent mass spectrometry significantly increases depth and reproducibility of results
Comprehensive, reproducible and precise analysis of large sample cohorts is one of the key
objectives of quantitative proteomics. Here, we present an implementation of data …
objectives of quantitative proteomics. Here, we present an implementation of data …
Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions
PM Müller, J Rademacher, RD Bagshaw… - Nature cell …, 2020 - nature.com
Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by
145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating …
145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating …
The BioGRID interaction database: 2015 update
A Chatr-Aryamontri, BJ Breitkreutz… - Nucleic acids …, 2015 - academic.oup.com
Abstract The Biological General Repository for Interaction Datasets (BioGRID:
http://thebiogrid. org) is an open access database that houses genetic and protein …
http://thebiogrid. org) is an open access database that houses genetic and protein …
SAINTexpress: improvements and additional features in Significance Analysis of INTeractome software
Abstract Significance Analysis of INTeractome (SAINT) is a statistical method for
probabilistically scoring protein–protein interaction data from affinity purification-mass …
probabilistically scoring protein–protein interaction data from affinity purification-mass …
Nutritional control of growth and development in yeast
JR Broach - Genetics, 2012 - academic.oup.com
Availability of key nutrients, such as sugars, amino acids, and nitrogen compounds, dictates
the developmental programs and the growth rates of yeast cells. A number of overlapping …
the developmental programs and the growth rates of yeast cells. A number of overlapping …
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
Chaperones are abundant cellular proteins that promote the folding and function of their
substrate proteins (clients). In vivo, chaperones also associate with a large and diverse set …
substrate proteins (clients). In vivo, chaperones also associate with a large and diverse set …