[HTML][HTML] Neurodegeneration cell per cell
S Balusu, R Praschberger, E Lauwers, B De Strooper… - Neuron, 2023 - cell.com
The clinical definition of neurodegenerative diseases is based on symptoms that reflect
terminal damage of specific brain regions. This is misleading as it tells little about the initial …
terminal damage of specific brain regions. This is misleading as it tells little about the initial …
[HTML][HTML] The single-cell and spatial transcriptional landscape of human gastrulation and early brain development
B Zeng, Z Liu, Y Lu, S Zhong, S Qin, L Huang, Y Zeng… - Cell Stem Cell, 2023 - cell.com
The emergence of the three germ layers and the lineage-specific precursor cells
orchestrating organogenesis represent fundamental milestones during early embryonic …
orchestrating organogenesis represent fundamental milestones during early embryonic …
[HTML][HTML] β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function
Down syndrome (DS) is a neurological disorder with multiple immune-related symptoms;
however, crosstalk between the CNS and peripheral immune system remains unexplored …
however, crosstalk between the CNS and peripheral immune system remains unexplored …
Pyramidal neurons form active, transient, multilayered circuits perturbed by autism-associated mutations at the inception of neocortex
Cortical circuits are composed predominantly of pyramidal-to-pyramidal neuron
connections, yet their assembly during embryonic development is not well understood. We …
connections, yet their assembly during embryonic development is not well understood. We …
[HTML][HTML] The impact of (ab) normal maternal environment on cortical development
NA Vasistha, K Khodosevich - Progress in Neurobiology, 2021 - Elsevier
The cortex in the mammalian brain is the most complex brain region that integrates sensory
information and coordinates motor and cognitive processes. To perform such functions, the …
information and coordinates motor and cognitive processes. To perform such functions, the …
[HTML][HTML] Gabrb3 is required for the functional integration of pyramidal neuron subtypes in the somatosensory cortex
Dysfunction of gamma-aminobutyric acid (GABA) ergic circuits is strongly associated with
neurodevelopmental disorders. However, it is unclear how genetic predispositions impact …
neurodevelopmental disorders. However, it is unclear how genetic predispositions impact …
[HTML][HTML] Autism-linked UBE3A gain-of-function mutation causes interneuron and behavioral phenotypes when inherited maternally or paternally in mice
The E3 ubiquitin ligase Ube3a is biallelically expressed in neural progenitors and glial cells,
suggesting that UBE3A gain-of-function mutations might cause neurodevelopmental …
suggesting that UBE3A gain-of-function mutations might cause neurodevelopmental …
Generation of rat forebrain tissues in mice
Interspecies blastocyst complementation (IBC) provides a unique platform to study
development and holds the potential to overcome worldwide organ shortages. Despite …
development and holds the potential to overcome worldwide organ shortages. Despite …
Subcellular mRNA localization and local translation of Arhgap11a in radial glial progenitors regulates cortical development
Summary mRNA localization and local translation enable exquisite spatial and temporal
control of gene expression, particularly in polarized, elongated cells. These features are …
control of gene expression, particularly in polarized, elongated cells. These features are …
ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling
Brain functionality relies on finely tuned regulation of gene expression by networks of non-
coding RNAs (ncRNAs) such as the one composed by the circular RNA ciRS-7 (also known …
coding RNAs (ncRNAs) such as the one composed by the circular RNA ciRS-7 (also known …