The contribution of astrocytes and microglia to traumatic brain injury

IP Karve, JM Taylor, PJ Crack - British journal of pharmacology, 2016 - Wiley Online Library
Traumatic brain injury (TBI) represents a major cause of death and disability in developed
countries. Brain injuries are highly heterogeneous and can also trigger other neurological …

Brain tissue responses to neural implants impact signal sensitivity and intervention strategies

TDY Kozai, AS Jaquins-Gerstl… - ACS chemical …, 2015 - ACS Publications
Implantable biosensors are valuable scientific tools for basic neuroscience research and
clinical applications. Neurotechnologies provide direct readouts of neurological signal and …

Controlled activation of TRPV1 channels on microglia to boost their autophagy for clearance of alpha‐synuclein and enhance therapy of Parkinson's disease

J Yuan, H Liu, H Zhang, T Wang, Q Zheng… - Advanced …, 2022 - Wiley Online Library
Parkinson's disease (PD) is characterized with accumulation of Lewy bodies with a major
component of fibrillar alpha‐synuclein (α‐syn). Herein, boosting PD therapeutic efficacy by …

Functional immune cell–astrocyte interactions

LM Sanmarco, CM Polonio, MA Wheeler… - Journal of Experimental …, 2021 - rupress.org
Astrocytes are abundant glial cells in the central nervous system (CNS) that control multiple
aspects of health and disease. Through their interactions with components of the blood …

Chemokines in neuron–glial cell interaction and pathogenesis of neuropathic pain

ZJ Zhang, BC Jiang, YJ Gao - Cellular and Molecular Life Sciences, 2017 - Springer
Neuropathic pain resulting from damage or dysfunction of the nervous system is a highly
debilitating chronic pain state and is often resistant to currently available treatments. It has …

Response of brain tissue to chronically implanted neural electrodes

VS Polikov, PA Tresco, WM Reichert - Journal of neuroscience methods, 2005 - Elsevier
Chronically implanted recording electrode arrays linked to prosthetics have the potential to
make positive impacts on patients suffering from full or partial paralysis. Such arrays are …

The role of microglia in amyloid clearance from the AD brain

CYD Lee, GE Landreth - Journal of neural transmission, 2010 - Springer
Abstract Alzheimer's disease (AD), the most prominent cause of senile dementia, is clinically
characterized by the extracellular deposition of β-amyloid (Aβ) and the intracellular …

[HTML][HTML] Reactive astrocytes: The nexus of pathological and clinical hallmarks of Alzheimer's disease

BR Price, LA Johnson, CM Norris - Ageing research reviews, 2021 - Elsevier
Astrocyte reactivity is a hallmark of neuroinflammation that arises with Alzheimer's disease
(AD) and nearly every other neurodegenerative condition. While astrocytes certainly …

Astrocytes, from brain glue to communication elements: the revolution continues

A Volterra, J Meldolesi - Nature Reviews Neuroscience, 2005 - nature.com
For decades, astrocytes have been considered to be non-excitable support cells of the brain.
However, this view has changed radically during the past twenty years. The recent …

Astrocytes are active players in cerebral innate immunity

C Farina, F Aloisi, E Meinl - Trends in immunology, 2007 - cell.com
Innate immunity is a constitutive component of the central nervous system (CNS) and relies
strongly on resident myeloid cells, the microglia. However, evidence is emerging that the …