Synthesis and biological activity of new indole based derivatives as potent anticancer, antioxidant and antimicrobial agents
Indoles have very critical roles to design new biologically active molecules in medicinal
chemistry. They display higher biological activities or create new biological properties when …
chemistry. They display higher biological activities or create new biological properties when …
Bioactive Analysis of Antibacterial Efficacy and Antioxidant Potential of Aloe barbadensis Miller Leaf Extracts and Exploration of Secondary Metabolites Using GC–MS …
S Palaniyappan, A Sridhar, M Arumugam… - Applied Biochemistry …, 2024 - Springer
Aloe barbadensis Miller (ABM) is a traditional medicinal plant all over the world. Numerous
studies were conducted to exhibit its medicinal properties and most of them were …
studies were conducted to exhibit its medicinal properties and most of them were …
New Schiff bases with thiophene ring: Synthesis, biological activities, and molecular docking study
In this study, the synthesis of Schiff bases containing substituted thiophene was carried out.
The compounds were characterized by Fourier transform infrared (FTIR), 1H and 13C NMR …
The compounds were characterized by Fourier transform infrared (FTIR), 1H and 13C NMR …
Synthesis, Optimization, ADME Analysis, and Antioxidant Activity of 2-(Arylethynyl)-3-ethynylthiophenes
Dialkynylthiophene derivatives were synthesized by using regio-and stereocontrolled Pd-
catalyzed Sonogashira coupling and desilylation reactions. The synthesized compounds …
catalyzed Sonogashira coupling and desilylation reactions. The synthesized compounds …
Identification of 3-bromo-1-ethyl-1H-indole as a potent anticancer agent with promising inhibitory effects on GST isozymes
Background: Indole-based heterocyclic compounds play important roles in pharmaceutical
chemistry due to their unexpected biological and pharmacological properties. Objective …
chemistry due to their unexpected biological and pharmacological properties. Objective …
Synthesis, cytotoxicity, antioxidant and antimicrobial activity of indole based novel small molecules
Aims: In this study experiments were carried out to explore antioxidant, antimicrobial,
cytotoxic properties of novel indole derivative 1-ethyl-2-phenyl-3-phenylethyl-3-thiophen-2 …
cytotoxic properties of novel indole derivative 1-ethyl-2-phenyl-3-phenylethyl-3-thiophen-2 …
1-(3-Methylthiophene-2-yl)-N-(3, 4, 5-trimethoxyphenyl) methanimine: Synthesis, Spectroscopic Characterization, Antileishmanial Activity, and DFT and In Silico …
(3-Methylthiophen-2-yl)-N-(3, 4, 5-trimethoxyphenyl) methanimine (1, MTM) was synthesized
from 3-methylthiophene-2-carbaldehyde and 3, 4, 5-trimethoxyaniline and characterized by …
from 3-methylthiophene-2-carbaldehyde and 3, 4, 5-trimethoxyaniline and characterized by …
A thiophene derivative, 2‐Bromo‐5‐(2‐(methylthio) phenyl) thiophene, has effective anticancer potential with other biological properties
Thiophene derivatives are studied intensively due to their anticancer, antimicrobial,
antioxidant and some other clinically important properties. In this study, the biological …
antioxidant and some other clinically important properties. In this study, the biological …
Synthesis of Ethynyl‐Thiophene Derivatives, Antioxidant Properties and ADME Analysis
Herein, novel alkyne based organic compounds, 2‐((2‐(methylthio) phenyl) ethynyl)
thiophene (MAT) and 2‐ethynyl‐3‐(phenylethynyl) thiophene (DAT), were designed and …
thiophene (MAT) and 2‐ethynyl‐3‐(phenylethynyl) thiophene (DAT), were designed and …
A validated LC-MS/MS method for the determination of mezlocillin in plasma: an adapted method for therapeutic drug monitoring in children
BH Tang, M Kan, XM Yang, RH Wang… - Current …, 2021 - ingentaconnect.com
Background: Mezlocillin is off-label used for the treatment of respiratory infections in
children. Therapeutic Drug Monitoring (TDM) data are also limited in children. A sensitive …
children. Therapeutic Drug Monitoring (TDM) data are also limited in children. A sensitive …