Role of receptor binding specificity in influenza A virus transmission and pathogenesis

M de Graaf, RAM Fouchier - The EMBO journal, 2014 - embopress.org
The recent emergence of a novel avian A/H 7 N 9 influenza virus in poultry and humans in C
hina, as well as laboratory studies on adaptation and transmission of avian A/H 5 N 1 …

Potential cross-species transmission of highly pathogenic avian influenza H5 subtype (HPAI H5) viruses to humans calls for the development of H5-specific and …

P Huang, L Sun, J Li, Q Wu, N Rezaei, S Jiang, C Pan - Cell discovery, 2023 - nature.com
In recent years, highly pathogenic avian influenza H5 subtype (HPAI H5) viruses have been
prevalent around the world in both avian and mammalian species, causing serious …

The episodic resurgence of highly pathogenic avian influenza H5 virus

R Xie, KM Edwards, M Wille, X Wei, SS Wong, M Zanin… - Nature, 2023 - nature.com
Highly pathogenic avian influenza (HPAI) H5N1 activity has intensified globally since 2021,
increasingly causing mass mortality in wild birds and poultry and incidental infections in …

A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors

TH Lin, X Zhu, S Wang, D Zhang, R McBride, W Yu… - Science, 2024 - science.org
In 2024, several human infections with highly pathogenic clade 2.3. 4.4 b bovine influenza
H5N1 viruses in the United States raised concerns about their capability for bovine-to …

Airborne transmission of influenza A/H5N1 virus between ferrets

S Herfst, EJA Schrauwen, M Linster, S Chutinimitkul… - science, 2012 - science.org
Highly pathogenic avian influenza A/H5N1 virus can cause morbidity and mortality in
humans but thus far has not acquired the ability to be transmitted by aerosol or respiratory …

Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets

M Imai, T Watanabe, M Hatta, SC Das, M Ozawa… - Nature, 2012 - nature.com
Highly pathogenic avian H5N1 influenza A viruses occasionally infect humans, but currently
do not transmit efficiently among humans. The viral haemagglutinin (HA) protein is a known …

Influenza hemagglutinin and neuraminidase membrane glycoproteins

SJ Gamblin, JJ Skehel - Journal of biological chemistry, 2010 - ASBMB
Considerable progress has been made toward understanding the structural basis of the
interaction of the two major surface glycoproteins of influenza A virus with their common …

Enabling the'host jump': structural determinants of receptor-binding specificity in influenza A viruses

Y Shi, Y Wu, W Zhang, J Qi, GF Gao - Nature Reviews Microbiology, 2014 - nature.com
The recent emergence of the H7N9 avian influenza A virus and its ability to infect humans
emphasize the epidemic and pandemic potential of these viruses. Interspecies transmission …

The repertoire of glycan determinants in the human glycome

RD Cummings - Molecular BioSystems, 2009 - pubs.rsc.org
The number of glycan determinants that comprise the human glycome is not known. This
uncertainty arises from limited knowledge of the total number of distinct glycans and glycan …

Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian host

Y Gao, Y Zhang, K Shinya, G Deng, Y Jiang, Z Li… - PLoS …, 2009 - journals.plos.org
Since 2003, H5N1 influenza viruses have caused over 400 known cases of human infection
with a mortality rate greater than 60%. Most of these cases resulted from direct contact with …