Bone and skeletal muscle are integrated organs and their coupling has been considered
mainly a mechanical one in which bone serves as attachment site to muscle while muscle …

Menopause is a risk factor for cardiometabolic diseases, including metabolic syndrome
(MetS), type 2 diabetes, and cardiovascular diseases. MetS is a constellation of …

Excess body weight due to obesity has traditionally been considered to have a positive
effect on bone; however, more recent findings suggest that bone quality is compromised …

Accumulating evidence supports a complex relationship between adiposity and
osteoporosis in overweight/obese individuals, with local interactions and endocrine …

Abstract Type 2 diabetes (T2D) is associated with numerous complications, including
increased risk of fragility fractures, despite seemingly protective factors [eg, normal bone …

Despite a clear association between type 2 diabetes (T2D) and fracture risk, the
pathogenesis of bone fragility in T2D has not been clearly elucidated. Insulin resistance is …

Adiponectin is a protein synthesized and secreted predominantly by adipocytes into the
peripheral blood. However, circulating adiponectin level is inversely related with body …

Context Numerous studies have demonstrated detrimental skeletal consequences following
bariatric surgery. Methods A working group of the European Calcified Tissue Society (ECTS) …

Physical inactivity has been recognized, by the World Health Organization as the fourth
cause of death (5.5% worldwide). On the contrary, physical activity (PA) has been …

Anorexia nervosa (AN) is a condition of severe low weight that is associated with low bone
mass, impaired bone structure, and reduced bone strength, all of which contribute to …