Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, accounting
for 25% of all childhood cancers. In the United States, approximately 3000 children aged 1 …

In late 1993 and early 1994, two distinct lines of research converged on a new tumor
suppressor gene located on human chromosome 9p21. The órst report was of the existence …

ACUTE LYMPHOBLASTIC leukemias (ALL) are charac-terized by clonal proliferation,
accumulation, and tissue infiltration of neoplastic cells. They are mainly regarded as …

The TEL (translocation–Ets–leukemia or ETV6) locus, which encodes an Ets family
transcription factor, is frequently rearranged in human leukemias of myeloid or lymphoid …

Whereas the improvement in outcome for children with acute lymphoblastic leukemia has
been gratifying, the poor outcome of patients who relapse warrants novel treatment …

TEL is a gene frequently involved in specific chromosomal translocations in human
leukemia and sarcoma that encodes a member of the ETS family of transcriptional …

Chromosomal translocations are one of the most common types of genetic rearrangements
and are molecular signatures for many types of cancers. They are considered as primary …

Background Renal medullary carcinoma (RMC) is a rare and highly aggressive neoplasm
that most often occurs in the setting of sickle cell trait or sickle cell disease (SCD). Most …

ETS proteins form one of the largest families of signal-dependent transcriptional regulators,
mediating cellular proliferation, differentiation and tumorigenesis. Most of the known ETS …

ETV6/CBFA2 (TEL/AML1) is the most frequent genetic abnormality associated with acute
lymphoblastic leukemias in children, and is associated with a favorable prognosis. To …