Oral delivery of anticancer drugs: challenges and opportunities

K Thanki, RP Gangwal, AT Sangamwar… - Journal of controlled …, 2013 - Elsevier
The present report focuses on the various aspects of oral delivery of anticancer drugs. The
significance of oral delivery in cancer therapeutics has been highlighted which principally …

A review of therapeutic challenges and achievements of methotrexate delivery systems for treatment of cancer and rheumatoid arthritis

SS Abolmaali, AM Tamaddon, R Dinarvand - Cancer chemotherapy and …, 2013 - Springer
Purpose Methotrexate (MTX) is one of the most widely studied and effective therapeutics
agents available to treat many solid tumors, hematologic malignancies, and autoimmune …

Interaction of anticancer drug methotrexate with DNA analyzed by electrochemical and spectroscopic methods

B Rafique, AM Khalid, K Akhtar, A Jabbar - Biosensors and Bioelectronics, 2013 - Elsevier
Electrochemical DNA biosensor was used to study the interaction of methotrexate (MTX)
with DNA immobilized on the bare surface of glassy carbon electrode (GCE). The binding …

[HTML][HTML] Preparation and assessment of chitosan-coated superparamagnetic Fe3O4 nanoparticles for controlled delivery of methotrexate

S Mohammadi-Samani, R Miri… - Research in …, 2013 - ncbi.nlm.nih.gov
In this study, Fe 3 O 4 superparamagnetic nanoparticles were synthesized and stabilized by
chitosan. Then the nanoparticles were characterized by Fourier transform infrared …

β-cyclodextrin modified hydrogels of kappa-carrageenan for methotrexate delivery

M Nikitina, N Kochkina, M Arinina, V Kulichikhin… - Pharmaceutics, 2023 - mdpi.com
This work is aimed at developing a kappa-carrageenan (kCR) gel with increased
methotrexate (MTX) content. β-Cyclodextrin (βCD), which is able to inclusion complex …

Improvement of pharmacologically relevant properties of methotrexate by solid dispersion with Pluronic F127

M Agafonov, S Ivanov, I Terekhova - Materials Science and Engineering: C, 2021 - Elsevier
Solid dispersion with Pluronic F127 was proposed as alternative approach to modify the
pharmacologically relevant properties of methotrexate (MTX). Solid dispersion of MTX with …

iota-Carrageenan hydrogels for methotrexate delivery

N Kochkina, M Nikitina, M Agafonov… - Journal of Molecular …, 2022 - Elsevier
To reduce the side effects associated with systemic drug administration, topical hydrogel on
the basis of iota-carrageenan, methotrexate and cyclodextrin was developed. Cyclodextrins …

Pegylated and amphiphilic Chitosan coated manganese ferrite nanoparticles for pH-sensitive delivery of methotrexate: Synthesis and characterization

Z Karimi, S Abbasi, H Shokrollahi, G Yousefi… - Materials Science and …, 2017 - Elsevier
Magnetic nanoparticles (MNPs) are the major class of nanoparticles (NPs) with specific
functional properties that make them good candidates for biomedical applications. Due to …

Bioreducible cross-linked core polymer micelles enhance in vitro activity of methotrexate in breast cancer cells

M Gulfam, T Matini, PF Monteiro, R Riva… - Biomaterials …, 2017 - pubs.rsc.org
Polymer micelles have emerged as promising carriers for controlled release applications,
however, several limitations of micelle-based drug delivery have also been reported. To …

Nanoparticles of Conjugated Methotrexate‐Human Serum Albumin: Preparation and Cytotoxicity Evaluations

A Taheri, F Atyabi, F Salman Nouri… - Journal of …, 2011 - Wiley Online Library
Methotrexate‐human serum albumin conjugates were developed by a simple carbodiimide
reaction. Methotrexate‐human serum albumin conjugates were then crosslinked with 1 …