In vitro three-dimensional (3D) cultures are emerging as novel systems with which to study
tissue development, organogenesis and stem cell behavior ex vivo. When grown in a 3D …

Recent studies have shown that the respiratory system has an extensive ability to respond to
injury and regenerate lost or damaged cells. The unperturbed adult lung is remarkably …

The cellular landscape of the human intestinal tract is dynamic throughout life, developing in
utero and changing in response to functional requirements and environmental exposures …

Developmental processes underlying normal tissue regeneration have been implicated in
cancer, but the degree of their enactment during tumor progression and under the selective …

Although the function of the mammalian pancreas hinges on complex interactions of distinct
cell types, gene expression profiles have primarily been described with bulk mixtures. Here …

Adult somatic tissues have proven difficult to expand in vitro, largely because of the
complexity of recreating appropriate environmental signals in culture. We have overcome …

Understanding pancreas development can provide clues for better treatments of pancreatic
diseases. However, the molecular heterogeneity and developmental trajectory of the early …

Although organ fibrosis causes significant morbidity and mortality in chronic diseases, the
lack of detailed knowledge about specific cellular contributors mediating fibrogenesis …

The liver is a central regulator of metabolism, and liver failure thus constitutes a major health
burden. Understanding how this complex organ develops during embryogenesis will yield …

Hepatocytes are replenished gradually during homeostasis and robustly after liver injury,. In
adults, new hepatocytes originate from the existing hepatocyte pool,,,,–, but the cellular …