Compounds containing a 1, 1-diaryl motif are numerous, and compounds of this type have
found use as catalysts and molecular building blocks, however, this review focusses solely …

Abstract 1, 2, 3, 4-Tetrahydro-β-carboline (THβC) scaffold is widespread in many natural
products (NPs) and synthetic compounds which show a variety of pharmacological activities …

The natural β-carboline alkaloids display similarities with neurotransmitters that can be
favorably exploited to design bioactive and bioavailable drugs for Alzheimer's disease (AD) …

Colorectal cancer is the third most common human cancer with frequent overexpression of
the cGMP-specific phosphodiesterase 5 (PDE5). In the present study, we investigated that …

Receptor Guanylyl Cyclase C (GC-C) was initially characterized as an important regulator of
intestinal fluid and ion homeostasis. Recent findings demonstrate that GC-C is also causally …

The design, synthesis and pharmacological activities of a group of 5, 5-
diphenylimidazolidine-2, 4-dione bearing anilide, phenacyl and benzylidene fragments 2 …

In drug discovery the reliable prediction of binding free energies is of crucial importance.
Methods that combine molecular mechanics force fields with continuum solvent models …

A novel series of substituted 2-thiohydantoin incorporated with benzoimidazole, pyrazole,
triazole and/or benzoxazole moieties has been synthesized using (E)-3-[1-(4-bromophenyl) …

Cyclic nucleotide phosphodiesterases (PDEs) are a superfamily of enzymes known to play a
critical role in the indirect regulation of several intracellular metabolism pathways through …

Sildenafil is the first phosphodiesterase-5 inhibitor used for the treatment of erectile
dysfunction. However, recent studies have been suggesting an antitumor effect of sildenafil …