Sickle cell disease and its variants constitute the most common inherited blood disorders
affecting millions of individuals worldwide. Significant information regarding the nature of the …

Hyponatremia is the most common electrolyte disorder in clinical practice and is associated
with increased morbidity and mortality. It is frequently encountered in hematologic patients …

The exact pathophysiology of severe COVID-19 is not entirely elucidated, but it has been
established that hyperinflammatory responses and cytokine storms play important roles. The …

Disordered erythropoiesis is a feature of many hematologic diseases, including sickle cell
disease (SCD). However, very little is known about erythropoiesis in SCD. Here, we show …

Introduction Sickle cell disease (SCD) is the most common genetic disease found in Africa
and throughout the world. It is responsible for a high rate of hemolysis, systemic …

Sickle cell disease (SCD) is a well-studied monogenetic disease with an established chronic
inflammatory component. The paradigm shift towards inflammation has made the …

Aim To evaluate the contributions of VWF to the clinical manifestation and severity of SCD
Design A systematic review of peer-reviewed articles published in English. The review was …

Recent evidence suggests that abnormalities involving CD4+ T lymphocytes are associated
with the pathophysiology of osteonecrosis (ON); however, few studies have addressed the …

Kawakawa (Piper excelsum) is an endemic medicinal plant widely consumed by Māori in
New Zealand. Presence of diverse biologically active phytochemicals in kawakawa may …

Sickle cell disease (SCD) is a lifelong blood disorder affecting approximately 100,000
people in the United States and is one of the most common monogenic diseases. A serious …