Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disorder. It is caused
by loss-of-function mutations in the dystrophin gene. Currently, there is no cure. A highly …

Antisense oligonucleotides (AONs) hold promise for therapeutic correction of many genetic
diseases via exon skipping, and the first AON-based drugs have entered clinical trials for …

Duchenne muscular dystrophy (DMD) is an X chromosome-linked disease characterized by
progressive physical disability, immobility, and premature death in affected boys. Underlying …

Duchenne muscular dystrophy (DMD) is a muscle disorder caused by DMD mutations and is
characterized by neurobehavioural comorbidities due to dystrophin deficiency in the brain …

Alterations in the Duchenne muscular dystrophy (DMD) gene have been associated with
enhanced stress reactivity in vertebrate species, suggesting a role for brain dystrophin in …

Loss of function mutations in the gene encoding dystrophin elicits a hypersensitive fear
response in mice and humans. In the dystrophin-deficient mdx mouse, this behaviour is …

The severity of brain comorbidities in Duchenne muscular dystrophy (DMD) depends on the
mutation position within the DMD gene and differential loss of distinct brain dystrophin …

Background Duchenne muscular dystrophy (DMD) is caused by the loss of dystrophin.
Severe and ultimately lethal, DMD progresses relatively slowly in that patients become …

Gene therapy and antisense approaches hold promise for the treatment of Duchenne
muscular dystrophy (DMD). The advantages of both therapeutic strategies can be combined …

Abstract Background The Duchenne and Becker muscular dystrophies (DMD, BMD) show
significant comorbid diagnosis for autism, and the genomic sequences encoding the …