Kinins are endogenous peptides that belong to the kallikrein-kinin system, which has been
extensively studied for over a century. Their essential role in multiple physiological and …

Personalized pain medicine aims to tailor pain treatment strategies for the specific needs
and characteristics of an individual patient, holding the potential for improving treatment …

With concurrent global epidemics of chronic pain and opioid use disorders, there is a critical
need to identify, target and manipulate specific cell populations expressing the mu-opioid …

Development of new non-addictive analgesics requires advanced strategies to differentiate
human pluripotent stem cells (hPSCs) into relevant cell types. Following principles of …

Neuropathic pain is a common, debilitating chronic pain condition caused by damage or a
disease affecting the somatosensory nervous system. Understanding the pathophysiological …

Rationale: Peripheral nerve block is a traditional perioperative analgesic method for its
precise pain control and low systemic toxicity. However, a single low dose of local anesthetic …

Neuropathic pain, a chronic condition resulting from nerve injury or dysfunction, presents
significant therapeutic challenges and is closely associated with oxidative stress and …

Inhibition of actin remodeling in nerves modulates action potential propagation and
therefore could be used to treat acute pain. N-001 is a novel protein analgesic engineered …

Around 20% of the American population have chronic pain and estimates in other Western
countries report similar numbers. This represents a major challenge for global health care …

Large-scale screening of molecules in organisms requires high-throughput and cost-
effective evaluating tools during preclinical development. Here, a novel in vivo screening …