Phage therapy in the postantibiotic era

FL Gordillo Altamirano, JJ Barr - Clinical microbiology reviews, 2019 - Am Soc Microbiol
Antibiotic resistance is arguably the biggest current threat to global health. An increasing
number of infections are becoming harder or almost impossible to treat, carrying high …

[HTML][HTML] Advantages and limitations of bacteriophages for the treatment of bacterial infections

N Principi, E Silvestri, S Esposito - Frontiers in pharmacology, 2019 - frontiersin.org
Bacteriophages (BPs) are viruses that can infect and kill bacteria without any negative effect
on human or animal cells. For this reason, it is supposed that they can be used, alone or in …

Phages for phage therapy: isolation, characterization, and host range breadth

P Hyman - Pharmaceuticals, 2019 - mdpi.com
For a bacteriophage to be useful for phage therapy it must be both isolated from the
environment and shown to have certain characteristics beyond just killing strains of the …

[HTML][HTML] Dynamic modulation of the gut microbiota and metabolome by bacteriophages in a mouse model

BB Hsu, TE Gibson, V Yeliseyev, Q Liu, L Lyon, L Bry… - Cell host & …, 2019 - cell.com
The human gut microbiome is comprised of densely colonizing microorganisms including
bacteriophages, which are in dynamic interaction with each other and the mammalian host …

[HTML][HTML] Formulation, stabilisation and encapsulation of bacteriophage for phage therapy

DJ Malik, IJ Sokolov, GK Vinner, F Mancuso… - Advances in colloid and …, 2017 - Elsevier
Against a backdrop of global antibiotic resistance and increasing awareness of the
importance of the human microbiota, there has been resurgent interest in the potential use of …

Standardized bacteriophage purification for personalized phage therapy

T Luong, AC Salabarria, RA Edwards, DR Roach - Nature protocols, 2020 - nature.com
The world is on the cusp of a post-antibiotic era, but researchers and medical doctors have
found a way forward—by looking back at how infections were treated before the advent of …

Phage therapy: What factors shape phage pharmacokinetics and bioavailability? Systematic and critical review

K Dąbrowska - Medicinal research reviews, 2019 - Wiley Online Library
Bacteriophages are not forgotten viruses anymore: scientists and practitioners seek to
understand phage pharmacokinetics in animals and humans, investigating bacteriophages …

[HTML][HTML] New insights into intestinal phages

R Sausset, MA Petit, V Gaboriau-Routhiau… - Mucosal …, 2020 - Elsevier
The intestinal microbiota plays important roles in human health. This last decade, the viral
fraction of the intestinal microbiota, composed essentially of phages that infect bacteria …

A historical overview of bacteriophage therapy as an alternative to antibiotics for the treatment of bacterial pathogens

X Wittebole, S De Roock, SM Opal - Virulence, 2014 - Taylor & Francis
The seemingly inexorable spread of antibiotic resistance genes among microbial pathogens
now threatens the long-term viability of our current antimicrobial therapy to treat severe …

Phages in nature

MRJ Clokie, AD Millard, AV Letarov, S Heaphy - Bacteriophage, 2011 - Taylor & Francis
Phages are the most abundant organisms in the biosphere and they are a ubiquitous feature
of prokaryotic existence. A bacteriophage is a virus which infects a bacterium. Archaea are …