Dietary essential fatty acids are the precursors for eicosanoids. Among the eicosanoids
derived from arachidonic acid, prostaglandin (PG) E2 is known to possess …

Distinctions between tumor necrosis factor, TNF-α, and lymphotoxin, TNF-β, have previously
been based on the differences between their protein sequences, biological activity, and …

Cyclooxygenase (COX) converts arachidonic acid to prostaglandin H2, which is further
metabolized to prostanoids. Two isoforms of COX exist: a constitutive (COX-1) and an …

Angiotensin II regulates the synthesis of proinflammatory cytokines and chemokines in the
kidney. Background Emerging evidence suggests that angiotensin II (Ang II) is not only a …

The role of prostaglandin E2 (PGE2) in the development of inflammatory symptoms and
cytokine production was evaluated in vivo using a neutralizing anti-PGE2 monoclonal …

A functional cDNA clone encoding mouse EP2 subtype of prostaglandin (PG) E receptor
was isolated from a mouse cDNA library by cross-hybridization with the mouse EP3 subtype …

Neutrophil adherence within the gastric microcirculation is thought to be a major step in the
pathogenesis of gastric mucosal damage induced by indomethacin. Pentoxifylline, a …

In addition to their capacity to induce pain, vasodilatation and fever, prostaglandins E (PGE)
exert anti‐inflammatory activities by inhibiting the release of pro‐inflammatory cytokines by …

1 This study investigates the role of tumour necrosis factor (TNF) in the induction of nitric
oxide synthase (NOS) by bacterial endotoxin (lipopolysaccharide; LPS) in a rat model of …

Prostanoids are oxygenated metabolites of C20 carboxylic acids, especially arachidonic
acid, and are regarded as modulators of cellular functions in various physiological and …