Gene expression in the aging brain depends on transcription signals generated by
senescent physiology, interacting with genetic and epigenetic programs. In turn …

Cognitive decline is a hallmark of the aging nervous system, characterized by increasing
memory loss and a deterioration of mental capacity, which in turn creates a favorable context …

We examine similar and differential effects of two senolytic treatments, ABT‐263 and
dasatinib+ quercetin (D+ Q), in preserving cognition, markers of peripheral senescence, and …

The brain's ability to process complex information relies on the constant supply of energy
through aerobic respiration by mitochondria. Neurons contain three anatomically distinct …

Doxorubicin (Dox), a widely used treatment for cancer, can result in chemotherapy‐induced
cognitive impairments (chemobrain). Chemobrain is associated with inflammation and …

With the aging process, elderly people present changes in their bodies that can lead them to
suffer several geriatric syndromes. The present study aimed to analyze and synthesize the …

Animal models of Alzheimer's Disease (AD) are attractive tools for preclinical, prodromal
drug testing. The TgF344-AD (Tg) rat exhibits cognitive deficits and 5 major hallmarks of AD …

The neuronal epigenome is highly sensitive to external events and its function is vital for
producing stable behavioral outcomes, such as the formation of long-lasting memories. The …

The current “one size fits all” approach to our cognitive aging population is not adequate to
close the gap between cognitive health span and lifespan. In this review article, we present …

Gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) has recently been shown
to promote oxidative stress and inflammation in the peripheral tissues, contributing to the …